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Literature summary for 2.7.11.26 extracted from

  • Kandasamy, A.D.; Schulz, R.
    Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts (2009), Cardiovasc. Res., 83, 698-706.
    View publication on PubMed
Search for more literature for 2.7.11.26

Activating Compound

Activating Compound Comment Organism Structure
additional information glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2-mediated proteolysis (dephosphorylation of Ser-9) in cardiomyoblasts MMP-2, GSK-3beta may be a target of matrix metalloproteinase-2 and its cleavage by matrix metalloproteinase-2 enhances its kinase activity, matrix metalloproteinase-2-mediated augmentation of GSK-3beta kinase activity may contribute to cardiac injury resulting from enhanced oxidative stress Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
 SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyoblast
-
 Rattus norvegicus
-
H9c2 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H-Arg-Arg-Arg-Ala-Ala-Glu-Glu-Leu-Asp-Ser-Arg-Ala-Gly-pSer-Pro-Gln-Leu-OH
-
 Rattus norvegicus ADP + ?
-
 ?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
 Rattus norvegicus
GSK-3beta
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus