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Literature summary for 2.7.11.26 extracted from

  • Ishiguro, K.; Takamatsu, M.; Tomizawa, K.; Omori, A.; Takahashi, M.; Arioka, M.; Uchida, T.; Imahori, K.
    Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments (1992), J. Biol. Chem., 267, 10897-10901.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
tubulin
-
Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
ATP strongly inhibited by elevated concentrations of ATP uncomplexed with magnesium Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
isoenzyme TPKII, SDS-PAGE Bos taurus
45000
-
isoenzyme TPKI, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein tau Bos taurus
-
ADP + protein tau phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
bovine
-

Purification (Commentary)

Purification (Comment) Organism
2 isoenzymes, TPKI and TPKII Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.001
-
isoenzyme TPKI, optimum conditions Bos taurus
0.056
-
isoenzyme TPKI Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + alpha-casein isoenzyme TPKI Bos taurus ADP + alpha-casein phosphate
-
?
ATP + beta-casein isoenzyme TPKII Bos taurus ADP + beta-casein phosphate
-
?
ATP + histone H1 isoenzyme TPKII Bos taurus ADP + histone H1 phosphate
-
?
ATP + histone H2a isoenzyme TPKII Bos taurus ADP + histone H2a phosphate
-
?
ATP + histone H2b isoenzyme TPKII Bos taurus ADP + histone H2b phosphate
-
?
ATP + histone H3 isoenzyme TPKII Bos taurus ADP + histone H3 phosphate
-
?
ATP + MAP2 isoenzyme TPKI and TPKII Bos taurus ADP + MAP2 phosphate
-
?
ATP + protein tau
-
Bos taurus ADP + protein tau phosphate
-
?
additional information TPKI cannot phosphorylate K1, K2 and K3 peptides, histones H1, H2A, H2B and H3 and beta casein Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
TPK
-
Bos taurus
TPKI
-
Bos taurus
TPKII
-
Bos taurus

pI Value

Organism Comment pI Value Maximum pI Value
Bos taurus isoenzyme TPKI, ?
-
9.4