Literature summary for 2.7.11.26 extracted from

Liu, S.J.; Zhang, J.Y.; Li, H.L.; Fang, Z.Y.; Wang, Q.; Deng, H.M.; Gong, C.X.; Grundke-Iqbal, I.; Iqbal, K.; Wang, J.Z.
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain (2004), J. Biol. Chem., 279, 50078-50088.

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Activating Compound

Activating Compound	Comment	Organism	Structure
cAMP	required for PKA activity	Rattus norvegicus
forskolin	activates PKA	Rattus norvegicus
additional information	tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain	Rattus norvegicus

Application

Application	Comment	Organism
medicine	PKA and GSK-3 are targets for the therapeutic treatment of Alzheimer's disease and other tauopathies	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
(Rp)-adenosine 3',5'-cyclic monophosphorothionate triethyl ammonium salt	inhibitor of PKA	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microtubule	-	Rattus norvegicus	5874	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [tau-protein]	Rattus norvegicus	abnormal hyperphosphorylation of tau by PKA and GSK-3 is associated with Alzheimer's disease and other tauopaties leading to neuronal degeneration	ADP + O-phospho-[tau-protein]	-	?
additional information	Rattus norvegicus	tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain, inhibition of tau hyperphosphorylation inhibits an associated loss in spatial memory	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + [tau-protein] = ADP + O-phospho-[tau-protein]	GSK-3 and PKA catalyze tau phosphorylation in the brain, while GSK-3 performs phosphorylation of glycogen synthase, EC 2.7.11.1, and other proteins in different tissues, and PKA performs phosphorylation of other proteins in different tissues	Rattus norvegicus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
hippocampus	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [tau-protein]	abnormal hyperphosphorylation of tau by PKA and GSK-3 is associated with Alzheimer's disease and other tauopaties leading to neuronal degeneration	Rattus norvegicus	ADP + O-phospho-[tau-protein]	-	?
ATP + [tau-protein]	phosphorylation by PKA at Ser214, and by GSK-3 at Ser404, Ser396, Ser198, Ser199, and Ser202	Rattus norvegicus	ADP + O-phospho-[tau-protein]	-	?
additional information	tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain, inhibition of tau hyperphosphorylation inhibits an associated loss in spatial memory	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
cAMP-dependent protein kinase A	-	Rattus norvegicus
glycogen synthase kinase-3	-	Rattus norvegicus
GSK-3	-	Rattus norvegicus
More	see also EC 2.7.11.1 and EC 2.7.11.11	Rattus norvegicus
PKA	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

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Release 2023.1 (January 2023)