Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | age-dependent increase in tau hyperphosphorylated at the AT-8 site and PHF-1 site, Cdk5 activity does not account for the age-dependent hyperphosphorylation of tau at the disease-related sites, it is mediated by GSK3 activity | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | disruption of regulation of GSK3 activity underlies tau hyperphosphorylation in neurodegenerative tauopathies. GSK3 may be a prime target for therapeutic intervention in tauopathies including Alzheimer disease | Mus musculus |
Cloned (Comment) | Organism |
---|---|
p25-induced Cdk5 over-activation of Cdk5 in young and old transgenic mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LiCl | pharmacological inhibition of GSK3 in old transgenic mice by chronic treatment with lithium, leads to a reduction of the age-dependent increase in tau hyperphosphorylation | Mus musculus | |
additional information | Cdk5 over-activation leads to inhibition of GSK3 in young transgenic mice, in old transgenic animals the inhibition of GSK3 is lost | Mus musculus | |
roscovitine | Cdk5 inhibitor | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 genetic background | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H1 | Cdk5 substrate | Mus musculus | ADP + histone H1 phosphate | - |
? | |
ATP + phospho-glycogen synthase peptide-2 | GSK3 substrate | Mus musculus | ADP + phosphorylated phospho-glycogen synthase peptide-2 | - |
? | |
ATP + protein tau | role of GSK3 as a key mediator of tau hyperphosphorylation, whereas Cdk5 acts as a modulator of tau hyperphosphorylation via the inhibitory regulation of GSK3 | Mus musculus | ADP + protein tau phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdk5 | - |
Mus musculus |
cyclin-dependent kinase 5 | - |
Mus musculus |
glycogen synthase kinase 3 | - |
Mus musculus |
GSK3 | - |
Mus musculus |