Literature summary for 2.7.11.26 extracted from

Koehler, C.; Dinekov, M.; Goetz, J.
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice (2013), Neurobiol. Aging, 34, 1369-1379.

Search for more literature for 2.7.11.26

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of several mutant mice, overview. Analysis of pathomechanisms in tauopathies using pR5 mice that express the P301L tau mutation found in familial forms of frontotemporal dementia, overview	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [tau-protein]	Mus musculus	-	ADP + O-phospho-[tau-protein]	-	?
ATP + [tau-protein]	Mus musculus C57BL/6	-	ADP + O-phospho-[tau-protein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q2NL51	-	-
Mus musculus	Q9WV60	-	-
Mus musculus C57BL/6	Q2NL51	-	-
Mus musculus C57BL/6	Q9WV60	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	GSK3 exists in neurons as 3 isoforms (GSK3alpha, beta, and beta2) that are encoded by 2 separate genes, immunohistochemic study of isozyme localization in neurons, detailed overview	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [tau-protein]	-	Mus musculus	ADP + O-phospho-[tau-protein]	-	?
ATP + [tau-protein]	-	Mus musculus C57BL/6	ADP + O-phospho-[tau-protein]	-	?

Synonyms

Synonyms	Comment	Organism
glycogen synthase kinase-3	-	Mus musculus
GSK3alpha	-	Mus musculus
GSK3beta	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	functional status of glycogen synthase kinase-3 and correlated appearance of distinct tau phospho-epitopes: neurons displaying increases in activation of phosphorylation of glycogen synthase kinase-3alpha/beta at tyrosine 279/216 also show an intense rather than moderate AT8 (phospho-Ser202/Thr205 tau) immunoreactivity, and immunoreactivity for AT100 (phospho-Ser212/Thr214 tau) and phosphorylated Ser422, phospho-epitopes associated with fibrillar tau pathology. These neurons are rare in 8.5-month-old, but numerous in 18.5- and 28-month-old pR5 mice. Tau- rather than an amyloid-beta peptide-induced pathology is associated with increased neuronal tyrosine phosphorylation. Tyrosine phosphorylation only increases in neurons with fibrillar tau pathology	Mus musculus

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Release 2023.1 (January 2023)