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Literature summary for 2.7.11.26 extracted from

  • Bernatik, O.; Pejskova, P.; Vyslouzil, D.; Hanakova, K.; Zdrahal, Z.; Cajanek, L.
    Phosphorylation of multiple proteins involved in ciliogenesis by tau tubulin kinase 2 (2020), Mol. Biol. Cell, 31, 1032-1046 .
    View publication on PubMed
Search for more literature for 2.7.11.26

Protein Variants

Protein Variants Comment Organism
D163A mutant with disabled kinase domain activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + CCDC92 Homo sapiens
-
 ADP + phosphorylated CCDC92
-
 ?
ATP + CEP164 Homo sapiens TTBK2-induced phosphorylations of CEP164 modulate its function, which in turn seems relevant for the process of cilia formation ADP + phosphorylated CEP164
-
 ?
ATP + CEP83 Homo sapiens
-
 ADP + phosphorylated CEP83
-
 ?
ATP + CEP89 Homo sapiens
-
 ADP + phosphorylated CEP89
-
 ?
ATP + DVL3 Homo sapiens
-
 ADP + phosphorylated DVL3
-
 ?
ATP + Rabin8 Homo sapiens
-
 ADP + phosphorylated Rabin8
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6IQ55
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + CCDC92
-
 Homo sapiens ADP + phosphorylated CCDC92
-
 ?
ATP + CEP164 TTBK2-induced phosphorylations of CEP164 modulate its function, which in turn seems relevant for the process of cilia formation Homo sapiens ADP + phosphorylated CEP164
-
 ?
ATP + CEP83
-
 Homo sapiens ADP + phosphorylated CEP83
-
 ?
ATP + CEP89
-
 Homo sapiens ADP + phosphorylated CEP89
-
 ?
ATP + DVL3
-
 Homo sapiens ADP + phosphorylated DVL3
-
 ?
ATP + Rabin8
-
 Homo sapiens ADP + phosphorylated Rabin8
-
 ?
additional information no activity with Rab8a Homo sapiens ?
-
-

Synonyms

Synonyms Comment Organism
tau tubulin kinase 2
-
 Homo sapiens
TTBK2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function tau tubulin kinase 2 is a key player in the cilium assembly pathway, controlling the final step of cilia initiation Homo sapiens