Activating Compound | Comment | Organism | Structure |
---|---|---|---|
tubulin | - |
Bos taurus |
Application | Comment | Organism |
---|---|---|
medicine | brain pathology in investigation of Alzheimers's disease, human tau phosphorylated by the kinase carries an epitope of the paired helical filaments that accumulate in the brain | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32000 | - |
gel filtration, SDS-PAGE | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein tau | Bos taurus | - |
ADP + protein tau phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
bovine | - |
Purification (Comment) | Organism |
---|---|
3 isoenzymes, tau protein kinase I and II and tau-tubulin kinase | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.01325 | - |
activity towards tubulin | Bos taurus |
0.01665 | - |
activity towards tau | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + alpha-casein | - |
Bos taurus | ADP + alpha-casein phosphate | - |
? | |
ATP + dephospho-beta-tubulin | isoenzyme tau-tubulin kinase | Bos taurus | ADP + beta-tubulin phosphate | - |
? | |
ATP + KAUSSPTVSRKTD | synthetic peptide p25/F3 | Bos taurus | ADP + KAUSSPTVSRKTD phosphate | - |
? | |
ATP + MADSRPKPANKTPPK | synthetic peptide F5f | Bos taurus | ADP + MADSRPKPANKTPPK phosphate | - |
? | |
ATP + MAP2 | - |
Bos taurus | ADP + MAP2 phosphate | - |
? | |
ATP + MARSRPK | synthetic peptide F5h | Bos taurus | ADP + MARSRPK phosphate | - |
? | |
ATP + PANKTPPKSPGEPAKDPAAK | synthetic peptide p25/F5a | Bos taurus | ADP + PANKTPPKSPGEPAKDPAAK phosphate | - |
? | |
ATP + protein tau | - |
Bos taurus | ADP + protein tau phosphate | - |
? | |
ATP + protein tau | phosphorylates tau and forms paired helical filament epitopes, tau/K1, K2, K3 and tau/4 repeat | Bos taurus | ADP + protein tau phosphate | - |
? | |
ATP + RADSRPK | synthetic peptide F5g | Bos taurus | ADP + RADSRPK phosphate | - |
? | |
ATP + RKRSRAE | synthetic peptide 8659 | Bos taurus | ADP + RKRSRAE phosphate | - |
? | |
ATP + RKRSRKE | synthetic peptide 8655 | Bos taurus | ADP + RKRSRKE phosphate | - |
? | |
ATP + RRREEETEEE | synthetic peptide CKII substrate | Bos taurus | ADP + RRREEETEEE phosphate | - |
? | |
additional information | novel isoenzyme, distinct from TPKI, TPKII CKI and CKII, no activity toward beta-casein and neurofilament, no reaction with synthetic peptides F5a PANKTPPKSPGEPAKDPAAK, F5n MADSRPK, F5d MADSRKPAN, F5e MADSRPAE and 8656 RKRARKE, only weak activity with histones H1, H2a and H2b as substrates | Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tau-protein kinase I | - |
Bos taurus |
tau-protein kinase II | - |
Bos taurus |
tau-tubulin kinase | - |
Bos taurus |