Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cisplatin | GSK-3 is activated by cisplatin treatment of HEI-OC1 cells, 0.02 mM cisplatin induces phosphorylation of Tyr216 GSK-3beta in HEI-OC1 cells but reduces the phosphorylation of Ser9 GSK-3beta, the activity of GSK-3beta is regulated negatively by the phosphorylation of Ser9 and positively by the phosphorylation of Tyr216 | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-cyanoethyl alsterpaullone | - |
Mus musculus | |
alsterpaullone | - |
Mus musculus | |
CT99021 | - |
Mus musculus | |
kenpaullone | - |
Mus musculus | |
LiCl | GSK-3-specific inhibitor | Mus musculus | |
SB 216763 | GSK-3-specific inhibitor | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEI-OC1 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3beta | - |
Mus musculus |
GSK-3beta | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | cisplatin-induced cytotoxicity may be associated with modulation of GSK-3 activation | Mus musculus |