Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.26 extracted from

  • Park, H.J.; Kim, H.J.; Bae, G.S.; Seo, S.W.; Kim, D.Y.; Jung, W.S.; Kim, M.S.; Song, M.Y.; Kim, E.K.; Kwon, K.B.; Hwang, S.Y.; Song, H.J.; Park, C.S.; Park, R.K.; Chong, M.S.; Park, S.J.
    Selective GSK-3beta inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells (2009), Hear. Res., 257, 53-62.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cisplatin GSK-3 is activated by cisplatin treatment of HEI-OC1 cells, 0.02 mM cisplatin induces phosphorylation of Tyr216 GSK-3beta in HEI-OC1 cells but reduces the phosphorylation of Ser9 GSK-3beta, the activity of GSK-3beta is regulated negatively by the phosphorylation of Ser9 and positively by the phosphorylation of Tyr216 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
2-cyanoethyl alsterpaullone
-
Mus musculus
alsterpaullone
-
Mus musculus
CT99021
-
Mus musculus
kenpaullone
-
Mus musculus
LiCl GSK-3-specific inhibitor Mus musculus
SB 216763 GSK-3-specific inhibitor Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEI-OC1 cell
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3beta
-
Mus musculus
GSK-3beta
-
Mus musculus

General Information

General Information Comment Organism
physiological function cisplatin-induced cytotoxicity may be associated with modulation of GSK-3 activation Mus musculus