Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Homo sapiens | - |
ADP + O-phospho-[tau-protein] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | - |
Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | the enzyme is a serine/threonine protein kinase | Homo sapiens | ADP + O-phospho-[tau-protein] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tauprotein kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | homology modeling, simulation and docking studies with L-glutamic acid, memantine, tacrine, and ropinirol ligands, of Tau-protein kinase, overview | Homo sapiens |
physiological function | the pathogenesis of Alzheimer's disease includes hyperphosphorylation of tau protein which results in the self-assembly of tangles of paired helical fragments and straight filaments. Defective tau protein causes the dementia leading to Alzheimer's disease | Homo sapiens |