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Literature summary for 2.7.11.26 extracted from
- Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells (2004), J. Neurosci. Res., 76, 110-120.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p25 | cyclin activator, dependent on, over 10fold increase in activity of CDK5 | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [tau-protein] | Mus musculus | hyperphosphorylation of tau by CDK5 is involved in apoptosis and neurodegeneration in Alzheimer's disease, overview | ADP + O-phospho-[tau-protein] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain cortex | - |
Mus musculus | - |
| central nervous system | - |
Mus musculus | - |
| CN1.4 cell | immortilized embryonic brain cortex cell line | Mus musculus | - |
| embryo | - |
Mus musculus | - |
| HTAU cell | immortilized embryonic brain cortex cell line overexpressing the human tau protein | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [tau-protein] | hyperphosphorylation of tau by CDK5 is involved in apoptosis and neurodegeneration in Alzheimer's disease, overview | Mus musculus | ADP + O-phospho-[tau-protein] | - |
? | |
| ATP + [tau-protein] | phosphorylation of the PHF-1 epitope at Ser396 and Ser404 by CDK5 | Mus musculus | ADP + O-phospho-[tau-protein] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdk5 | - |
Mus musculus |
| CDK5/p25 | - |
Mus musculus |
| cyclin-dependent kinase-5 | - |
Mus musculus |
| More | CDK5 is a unique member of the CDK family, see also EC 2.7.11.22 | Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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