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Literature summary for 2.7.11.26 extracted from

  • Castano, Z.; Gordon-Weeks, P.R.; Kypta, R.M.
    The neuron-specific isoform of GSK-3beta is required for axon growth (2010), J. Neurochem., 113, 117-130.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortical neuron
-
Homo sapiens
-
SH-SY5Y cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau
-
Homo sapiens ADP + protein tau phosphate
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
-
Homo sapiens
GSK-3alpha isoform Homo sapiens
GSK-3beta1 isoform Homo sapiens
GSK-3beta2 neuron-specific isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the neuron-specific isoform GSK-3beta2 is required for axon growth by phosphorylating microtubule-associated proteins including protein tau Rattus norvegicus