Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.26 extracted from

  • Bush, M.L.; Miyashiro, J.S.; Ingram, V.M.
    Activation of a neurofilament kinase, a tau kinase, and a tau phosphatase by decreased ATP levels in nerve growth factor-differentiated PC-12 cells (1995), Proc. Natl. Acad. Sci. USA, 92, 1861-1865.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.26

Activating Compound

Activating Compound Comment Organism Structure
carbonyl cyanide p-trifluoromethoxyphenylhydrazone
-
 Rattus norvegicus

Application

Application Comment Organism
medicine brain pathology in investigation of Alzheimers's disease, human tau phosphorylated by the kinase carries an epitope of the paired helical filaments that accumulate in the brain Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ATP strongly inhibited by elevated concentrations of ATP uncomplexed with magnesium Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein tau Rattus norvegicus
-
 ADP + protein tau phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 pheochromacytoma PC-12 cells
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
neuron neurofibrillary tangles Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tau
-
 Rattus norvegicus ADP + protein tau phosphate
-
 ?

Synonyms

Synonyms Comment Organism
brain proteinkinase PK40erk
-
 Rattus norvegicus