Literature summary for 2.7.11.26 extracted from

Suzuki, K.; Kawakami, F.; Sasaki, H.; Maruyama, H.; Ohtsuki, K.
Biochemical characterization of tau protein and its associated syndapin 1 and protein kinase Cepsilon for their functional regulation in rat brain (2009), Biochim. Biophys. Acta, 1790, 188-197.

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Activating Compound

Activating Compound	Comment	Organism	Structure
cholesterol 3-sulfate	potent stimulator for the GSK-3beta-mediated phosphorylation of tau protein (about 10fold stimulation in the presence of 0.003 mM)	Oryctolagus cuniculus
D-galactosylceramide-3-O-sulfate	potent stimulator for the GSK-3beta-mediated phosphorylation of tau protein (about 11fold stimulation in the presence of 0.003 mM)	Oryctolagus cuniculus
syndapin 1	highly stimulates the GSK-3beta-mediated phosphorylation of protein tau (about 4.3fold stimulation in the presence of 0.003 mM)	Oryctolagus cuniculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	protein tau-associated novel protein kinase Cepsilon suppresses the GSK-3beta-mediated phosphorylation of protein tau through the phosphorylation of GSK-3beta by the kinase in vitro	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
muscle	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + protein tau	protein tau primed by CK1 functions as an effective phosphate acceptor for GSK-3beta	Oryctolagus cuniculus	ADP + protein tau phosphate	-	?

Synonyms

Synonyms	Comment	Organism
glycogen synthase kinase-3beta	-	Oryctolagus cuniculus
GSK-3beta	-	Oryctolagus cuniculus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Oryctolagus cuniculus

General Information

General Information	Comment	Organism
physiological function	the GSK-3beta-mediated high phosphorylation of protein tau induces synapse loss and neuronal death	Oryctolagus cuniculus

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Release 2023.1 (January 2023)