3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase This is an abbreviated version! For detailed information about alkylglycerophosphoethanolamine phosphodiesterase, go to the full flat file .
Reaction
1-alkyl-sn-glycero-3-phosphoethanolamine +
H2O =
1-alkyl-sn-glycerol 3-phosphate +
ethanolamine
Synonyms (ecto)nucleotide pyrophosphatase/phosphodiesterase 2 [(E)NPP2], ATX, ATX/lysoPLD, ATX/NPP2, AtxB, ATXgamma, autocrine motility factor, autotaxin, autotaxin (ATX), autotaxin beta, autotaxin gamma, autotaxin/lysoPLD, ecto-nucleotide pyrophosphatase/phosphodiesterase-2, ectonucleotide pyrophosphatase phosphodiesterase-2, ectonucleotide pyrophosphatase/phosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase 2, ENPP, ENPP2, GDE1, GDE4, GDE7, GDPD1, GDPD3, glycerophosphodiesterase, hATX, Heminecrolysin, human autotaxin, human autotaxin alpha, human autotaxin beta, LPLD, lyso-PLD, lysophospholipase D, lysophospholipase-D, lysoPLD, lysoPLD autotaxin, lysoPLD/NPP2, mATX, mATXgamma, More, NPP-2, NPP2, NPP2alpha, NPP2gamma, nucleotide phosphodiesterase/pyrophosphatase (NPP), nucleotide pyrophosphatase-phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase 2, PD-Ialpha, PD-Ialpha/ATX, phosphodiesterase Ialpha, phosphodiesterase Ialpha/autotoxin, phosphodiesterase, alkylglycerophosphorylethanolamine, PLD, rhATX S48, zATX
ECTree
Synonyms
Synonyms on EC 3.1.4.39 - alkylglycerophosphoethanolamine phosphodiesterase
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(ecto)nucleotide pyrophosphatase/phosphodiesterase 2 [(E)NPP2]
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multi-functional and multi-modular, 3 splice variants/isoforms of ATX identified in both human and mouse (autotaxin alpha, beta and gamma, with autotaxin gamma being identical to PD-Ialpha)
ATXgamma
from human brain cDNA libary, 889 amino acids, lacks exon 12, new human variant, named autotaxin gamma
autocrine motility factor
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ecto-nucleotide pyrophosphatase/phosphodiesterase-2
ectonucleotide pyrophosphatase phosphodiesterase-2
ectonucleotide pyrophosphatase/phosphodiesterase
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ectonucleotide pyrophosphatase/phosphodiesterase 2
human autotaxin alpha
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nucleotide phosphodiesterase/pyrophosphatase (NPP)
nucleotide pyrophosphatase-phosphodiesterase
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belongs to the nucleotide pyrophosphatase (NPP) family of ectoenzymes and exoenzymes
nucleotide pyrophosphatase/phosphodiesterase 2
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PD-Ialpha/ATX
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multi-functional and multi-modular, 3 splice variants/isoforms of ATX identified in both human and mouse (autotaxin alpha, beta and gamma, with autotaxin gamma being identical to PD-Ialpha)
phosphodiesterase Ialpha
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phosphodiesterase Ialpha/autotoxin
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multi-functional and multi-modular, 3 splice variants/isoforms of ATX identified in both human and mouse (autotaxin alpha, beta and gamma, with autotaxin gamma being identical to phosphodiesterase Ialpha)
phosphodiesterase, alkylglycerophosphorylethanolamine
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rhATX S48
recombinant human ATX (rhATX S48) from prokaryotic cells
additional information
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molecular identity of autotoxin and enzyme
ATX
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ATX
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663885 , 666223 , 666527 , 670114 , 697080 , 701580 , 701638 , 702025 , 702693 , 703104 , 705057 , 705456 , 706456 , 706577 , 714038 , 714422 , 714443 , 714603 , 715218 , 715631 , 715637 , 729338 , 729701 , 730155 , 730301
ATX
one of the well-known tumor malignant factors
ATX
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665507 , 678439 , 680681 , 681910 , 695455 , 697490 , 703366 , 704356 , 704588 , 705323 , 705706 , 706456 , 706564 , 716316 , 729338 , 730155 , 730301
autotaxin
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autotaxin
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6 , 663457 , 663885 , 664939 , 665229 , 666223 , 666527 , 670114 , 679257 , 681769 , 697080 , 698987 , 701580 , 701638 , 702025 , 702693 , 703104 , 705057 , 705456 , 706456 , 706577 , 713665 , 714038 , 714106 , 714422 , 714443 , 714603 , 715218 , 715631 , 715637 , 729338 , 729701 , 730155 , 730301
autotaxin
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type II ectonucleotide pyrophosphate phosphodiesterase enzyme, member of the nucleotide pyrophosphatase/phosphodiesterase family of ectoenzymes (E-NPP) that hydrolyze phosphodiester bonds of various nucleotides and nucleotide derivatives
autotaxin
type II ectonucleotide pyrophosphate phosphodiesterase enzyme, member of the nucleotide pyrophosphatase/phosphodiesterase family of ectoenzymes (E-NPP) that hydrolyze phosphodiester bonds of various nucleotides and nucleotide derivatives
autotaxin
Loxosceles sp.
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autotaxin
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665507 , 678439 , 679137 , 680681 , 695455 , 697490 , 703366 , 704356 , 704588 , 705323 , 706456 , 706564 , 716316 , 729338 , 730155 , 730301
autotaxin
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a secreted form of lysophospholipase D
autotaxin
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essential for blood vessel formation during development
autotaxin
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member of the phosphodiesterase family of enzymes
autotaxin
type II ectonucleotide pyrophosphate phosphodiesterase enzyme, member of the nucleotide pyrophosphatase/phosphodiesterase family of ectoenzymes (E-NPP) that hydrolyze phosphodiester bonds of various nucleotides and nucleotide derivatives
autotaxin/lysoPLD
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belongs to a family of six NPP enzymes, only autotaxin/lysoPLD has activity against phospho- and sphingolipid substrates
autotaxin/lysoPLD
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belongs to a family of six NPP enzymes, only autotaxin/lysoPLD has activity against phospho- and sphingolipid substrates
ecto-nucleotide pyrophosphatase/phosphodiesterase-2
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ecto-nucleotide pyrophosphatase/phosphodiesterase-2
Loxosceles sp.
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ecto-nucleotide pyrophosphatase/phosphodiesterase-2
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ecto-nucleotide pyrophosphatase/phosphodiesterase-2
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ectonucleotide pyrophosphatase phosphodiesterase-2
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ectonucleotide pyrophosphatase phosphodiesterase-2
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ectonucleotide pyrophosphatase/phosphodiesterase 2
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ectonucleotide pyrophosphatase/phosphodiesterase 2
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ENPP2
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GDE1
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GDE7
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GDPD3
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glycerophosphodiesterase
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glycerophosphodiesterase
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lyso-PLD
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lysophospholipase D
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lysophospholipase D
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6 , 663457 , 663885 , 664939 , 665229 , 666223 , 666527 , 670114 , 679257 , 679280 , 680925 , 681769 , 697080 , 701580 , 702025 , 705057 , 706456 , 713665 , 714038 , 714443 , 714603 , 715218 , 715631 , 729338 , 729701 , 730155 , 730301
lysophospholipase D
Loxosceles sp.
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lysophospholipase D
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678439 , 679137 , 679864 , 680681 , 680925 , 703366 , 704356 , 704588 , 706456 , 714339 , 729338 , 730155 , 730301
lysophospholipase D
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promotes cell migration, metastasis, and angiogenesis
lysophospholipase D
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lysophospholipase D
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lysophospholipase D
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lysoPLD
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lysoPLD
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6 , 663457 , 664939 , 665229 , 666527 , 679280 , 681769 , 698987 , 700238 , 702025 , 703104 , 706456 , 714106 , 715218 , 729701 , 730155
lysoPLD
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regulates the blood levels of lysophosphatidic acid (LPA)
lysoPLD
Loxosceles sp.
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lysoPLD
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plasma lysoPLD is predominant form (863 amino acids), 2 further forms known - first contains 52 residue and second contains 24 residue insertions close to phosphodieseterase domain
lysoPLD
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purified from rat brain nucleus fractions, has the ability to hydrolyze the ester-bond between phoshate and choline in 1-palmitoyl-glycerophoshorylcholine
lysoPLD autotaxin
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nucleotide pyrophosphatase/phosphodiesterase, catalyzes hydrolysis via an active site threonine
lysoPLD autotaxin
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nucleotide pyrophosphatase/phosphodiesterase, catalyzes hydrolysis via an active site threonine
NPP-2
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NPP2
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NPP2alpha
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nucleotide phosphodiesterase/pyrophosphatase (NPP)
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nucleotide phosphodiesterase/pyrophosphatase (NPP)
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PLD
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