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Literature summary for 3.1.4.39 extracted from

  • Wu, T.; Kooi, C.V.; Shah, P.; Charnigo, R.; Huang, C.; Smyth, S.S.; Morris, A.J.
    Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration (2014), FASEB J., 28, 861-870.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.39

Inhibitors

Inhibitors Comment Organism Structure
PF8380
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is a secreted Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required for cell surface/intergrin binding Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the recombinant enzyme promotes MDA-MB-231 breast cancer cell and mouse aortic vascular smooth muscle cell migration in lysophosphatidic acid-dependent and -independent ways. The enzyme also shows nucleotide phosphodiesterase activity with nucleotide derivative 4-nitrophenyl-TMP as a substrate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ATX
-
 Homo sapiens
autotaxin
-
 Homo sapiens
lysophospholipase D
-
 Homo sapiens
lysoPLD
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00001
-
 PF8380 pH and temperature not specified in the publication Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme promotes MDA-MB-231 breast cancer cell and mouse aortic vascular smooth muscle cell migration in lysophosphatidic acid-dependent and -independent ways, overview. The enzyme binds to integrin adhesion receptors required for cell migration. Integrin-mediated cell surface binding results in enzyme uptake and intracellular trafficking, critical for the ability of the enzyme to promote rapid directionally persistent MDA-MB-231 cell migration Homo sapiens