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Literature summary for 3.1.4.39 extracted from

  • Federico, L.; Pamuklar, Z.; Smyth, S.S.; Morris, A.J.
    Therapeutic potential of autotaxin/lysophospholipase d inhibitors (2008), Curr. Drug Targets, 9, 698-708.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.39

Inhibitors

Inhibitors Comment Organism Structure
1-acyl glycerol 3-phosphate also fatty alcohol phosphates (structurally 1-acyl glycerol 3-phosphate analogs) Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information capable of hydrolyzing sphingosylphosphorylcholine with a significantly higher km-value, also able to hydrolyze nucleotide triphosphates di-adenosine polyphosphates and artificial phosphodiester substrates such as p-nitrophenyl thymidine phosphate with Km-values close to 1 and optimal activity observed at alkaline pH Mus musculus
0.1
-
 1-alkyl-sn-glycero-3-phosphoethanolamine achieved under optimal assay conditions, almost same results in blood plasma Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O Mus musculus
-
 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
-
 r

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Mus musculus 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
-
 r

Synonyms

Synonyms Comment Organism
ATX
-
 Mus musculus
autotaxin
-
 Mus musculus
lysoPLD plasma lysoPLD is predominant form (863 amino acids), 2 further forms known - first contains 52 residue and second contains 24 residue insertions close to phosphodieseterase domain Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0001
-
 1-acyl glycerol 3-phosphate CPF4 FRET assay (change of fluorescence intensity), inihibition involves both a reduction in vmax and an increase in km, binding affinity is 1000fold stronger than to 1-alkyl-sn-glycero-3-phosphoethanolamine and analogue substrates Mus musculus