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Literature summary for 3.1.4.39 extracted from

  • Fotopoulou, S.; Oikonomou, N.; Grigorieva, E.; Nikitopoulou, I.; Paparountas, T.; Thanassopoulou, A.; Zhao, Z.; Xu, Y.; Kontoyiannis, D.L.; Remboutsika, E.; Aidinis, V.
    ATX expression and LPA signalling are vital for the development of the nervous system (2010), Dev. Biol., 339, 451-464.
    View publication on PubMed
Search for more literature for 3.1.4.39

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lysophosphatidylcholine + H2O Mus musculus
-
 lysophosphatidic acid + choline
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FS-3 + H2O
-
 Mus musculus ?
-
 ?
lysophosphatidylcholine + H2O
-
 Mus musculus lysophosphatidic acid + choline
-
 ?

Synonyms

Synonyms Comment Organism
ATX
-
 Mus musculus
autotaxin
-
 Mus musculus
ENPP2
-
 Mus musculus
lysophospholipase D
-
 Mus musculus
lysoPLD
-
 Mus musculus

General Information

General Information Comment Organism
malfunction E9.5 ATX null mutants exhibit a failure of neural tube closure, most likely independent of the circulatory failure, which correlates with decreased cell proliferation and increased cell death, obligatory deletion results to embryonic lethality most likely due to aberrant vascular branching morphogenesis and chorio-allantoic fusion Mus musculus
physiological function ATX expression and lysophosphatidic acid signalling are vital for the development of the nervous system, ATX and lysophosphatidic acid are necessary for embryonic HIF-1a expression Mus musculus