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Literature summary for 3.1.4.39 extracted from

  • Koike, S.; Keino-Masu, K.; Ohto, T.; Sugiyama, F.; Takahashi, S.; Masu, M.
    Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac (2009), J. Biol. Chem., 284, 33561-33570.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lysophosphatidylcholine + H2O Mus musculus
-
 lysophosphatidic acid + choline
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
yolk sac from E7.5 to E9.5, Enpp2 mRNA is abundantly expressed in the visceral endoderm cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lysophosphatidylcholine + H2O
-
 Mus musculus lysophosphatidic acid + choline
-
 ?

Synonyms

Synonyms Comment Organism
ATX
-
 Mus musculus
autotaxin
-
 Mus musculus
lysophospholipase D
-
 Mus musculus

General Information

General Information Comment Organism
malfunction in Enpp2 knockout mouse embryos, lysosomes in the visceral endoderm cells are fragmented Mus musculus
physiological function constitutive activationof the Rho-ROCK-LIM kinase pathway by extracellular production of lysophosphatidic acid by the action of autotaxin is required to maintain the large size of lysosomes in visceral endoderm cells Mus musculus