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Literature summary for 3.1.4.39 extracted from
- Lysophospholipase D and its role in LPA production (2004), Cell. Signal., 16, 975-981.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | extracellular enzyme | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | extracellular enzyme | Homo sapiens | |
| ATP | extracellular enzyme | Homo sapiens | |
| Cu2+ | the inhibition of extracellular enzyme can be prevented by 2,6-di-tert-butyl-4-hydroxy-methylphenol | Rattus norvegicus | |
| EDTA | extracellular enzyme | Homo sapiens | |
| EDTA | inhibition of extracellular enzyme | Rattus norvegicus | |
| p-hydroxymercuribenzoate | the inhibition of the microsomal enzyme can be prevented by glutathione and dithiothreitol | Rattus norvegicus | |
| serine esterase inhibitors | inhibition of extracellular enzyme | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
| extracellular | - |
Rattus norvegicus | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Oryctolagus cuniculus | |
| Ca2+ | microsomal enzyme | Rattus norvegicus | |
| Co2+ | extracellular enzyme | Rattus norvegicus | |
| Mg2+ | low effect in rabbit kidney | Oryctolagus cuniculus | |
| Mg2+ | microsomal enzyme | Rattus norvegicus | |
| Mn2+ | extracellular enzyme | Rattus norvegicus | |
| Ni2+ | extracellular enzyme | Rattus norvegicus | |
| Zn2+ | extracellular enzyme | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | the product lysophosphatidic acid mediates multiple biological functions | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | medium of cultured adipocytes | Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| epithelial cell | - |
Rattus norvegicus | - |
| gastric mucosa | - |
Rattus norvegicus | - |
| kidney | - |
Oryctolagus cuniculus | - |
| liver | - |
Rattus norvegicus | - |
| plasma | - |
Homo sapiens | - |
| plasma | - |
Rattus norvegicus | - |
| plasma | - |
Oryctolagus cuniculus | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-alkyl-sn-glycero-3-phosphocholine + H2O | - |
Rattus norvegicus | 1-alkyl-sn-glycero-3-phosphate + choline | - |
? | |
| 1-O-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + H2O | the microsomal enzyme | Rattus norvegicus | 1-O-alkyl-2-lyso-sn-glycero-3-phosphate + ethanolamine | the microsomal enzyme | ? | |
| additional information | the microsomal enzymes prefer alkyl-lysophospholipids, the extracellular enzyme prefer acyl-phospholipids, but can use alkyl-lysophospholipids | Rattus norvegicus | ? | - |
? | |
| additional information | the plasma enzyme hydrolyzes acyl-, alkyl- and alkenyl-lysophophatidylcholines | Homo sapiens | ? | - |
? | |
| additional information | the product lysophosphatidic acid mediates multiple biological functions | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | molecular identity of autotoxin and enzyme | Homo sapiens |
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