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3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase

This is an abbreviated version!
For detailed information about alkylglycerophosphoethanolamine phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.39

Reaction

1-alkyl-sn-glycero-3-phosphoethanolamine
+
H2O
=
1-alkyl-sn-glycerol 3-phosphate
 +
ethanolamine

Synonyms

(ecto)nucleotide pyrophosphatase/phosphodiesterase 2 [(E)NPP2], ATX, ATX/lysoPLD, ATX/NPP2, AtxB, ATXgamma, autocrine motility factor, autotaxin, autotaxin (ATX), autotaxin beta, autotaxin gamma, autotaxin/lysoPLD, ecto-nucleotide pyrophosphatase/phosphodiesterase-2, ectonucleotide pyrophosphatase phosphodiesterase-2, ectonucleotide pyrophosphatase/phosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase 2, ENPP, ENPP2, GDE1, GDE4, GDE7, GDPD1, GDPD3, glycerophosphodiesterase, hATX, Heminecrolysin, human autotaxin, human autotaxin alpha, human autotaxin beta, LPLD, lyso-PLD, lysophospholipase D, lysophospholipase-D, lysoPLD, lysoPLD autotaxin, lysoPLD/NPP2, mATX, mATXgamma, More, NPP-2, NPP2, NPP2alpha, NPP2gamma, nucleotide phosphodiesterase/pyrophosphatase (NPP), nucleotide pyrophosphatase-phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase 2, PD-Ialpha, PD-Ialpha/ATX, phosphodiesterase Ialpha, phosphodiesterase Ialpha/autotoxin, phosphodiesterase, alkylglycerophosphorylethanolamine, PLD, rhATX S48, zATX

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase

Crystallization

Crystallization on EC 3.1.4.39 - alkylglycerophosphoethanolamine phosphodiesterase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified recombinant ATX alpha isoform, hanging-drop vapour diffusion method, X-ray diffraction structure determination and analysis at 3.0 A resolution
-
ATX alone and in complex with LPAs with different acyl-chain lengths and saturations, X-ray diffraction structure determination and analysis at 1.7-2.0 A resolution
-
crystal structure determination and analysis of enzyme in complexes with inhibitors 2BoA, 3BoA, and 4BoA, at 1.95 A, 1.90 A, and 1.75 A resolution
catalytic domain of NPP2 modeled on the known crystal structure of NPP from Xanthomonas axonopodis. Catalytic activity of NPP2 is critically dependent on the presence of a Man8/9GlcNAc2 moiety on Asn-524, a site that is phylogenetically conserved, not only in NPP2 but also in six of seven NPP isozymes. Suggestion that this glycan chain has a structural function and is involved in the interaction between the catalytic and nuclease-like domains of NPP2
enzyme crystal structure analysis, PDB entry 2XR9., overview
-
purified recombinant ATX, hanging drop vapour diffusion method, usage of crystallization solution 0.1 M MIB buffer, pH 8, 25% w/v PEG 1500, or 0.1 M MIB buffer, pH 9, 25% w/v PEG 1500, or 0.2 M sodium citrate, 20% w/v PEG 3350, X-ray diffraction structure determination and analysis at 2.0-2.6 A resolution
purified recombinant enzyme, ATX alone and in complex with a small-molecule inhibitor HA155, X-ray diffraction structure determination and analysis at 2.0 A resolution, molecular replacement and single-wavelength anomalous dispersion