3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase

This is an abbreviated version!
For detailed information about alkylglycerophosphoethanolamine phosphodiesterase, go to the full flat file.

Reaction

Synonyms

(ecto)nucleotide pyrophosphatase/phosphodiesterase 2 [(E)NPP2], ATX, ATX/lysoPLD, ATX/NPP2, AtxB, ATXgamma, autocrine motility factor, autotaxin, autotaxin (ATX), autotaxin beta, autotaxin gamma, autotaxin/lysoPLD, ecto-nucleotide pyrophosphatase/phosphodiesterase-2, ectonucleotide pyrophosphatase phosphodiesterase-2, ectonucleotide pyrophosphatase/phosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase 2, ENPP, ENPP2, GDE1, GDE4, GDE7, GDPD1, GDPD3, glycerophosphodiesterase, hATX, Heminecrolysin, human autotaxin, human autotaxin alpha, human autotaxin beta, LPLD, lyso-PLD, lysophospholipase D, lysophospholipase-D, lysoPLD, lysoPLD autotaxin, lysoPLD/NPP2, mATX, mATXgamma, More, NPP-2, NPP2, NPP2alpha, NPP2gamma, nucleotide phosphodiesterase/pyrophosphatase (NPP), nucleotide pyrophosphatase-phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase 2, PD-Ialpha, PD-Ialpha/ATX, phosphodiesterase Ialpha, phosphodiesterase Ialpha/autotoxin, phosphodiesterase, alkylglycerophosphorylethanolamine, PLD, rhATX S48, zATX

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.4 Phosphoric-diester hydrolases

                3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase

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Results	in table
7	Activating Compound
21	AA Sequence
24	Application
1	CAS Registry Number
38	Cloned(Commentary)
7	Crystallization (Commentary)
901	Disease/ Diagnostics
9	Expression
64	General Information
2	General Stability
54	IC50 Value
243	Inhibitors
2	kcat/KM [mM/s]
71	Ki Value [mM]
46	KM Value [mM]
50	Localization
58	Metals/Ions
27	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
335	Organism
5	Pathway
61	PDB ID
15	pH Optimum
4	pH Range
17	Posttranslational Modification
75	Protein Variants
18	Purification (Commentary)
1	Reaction
12	Reaction Type
113	Reference
161	Source Tissue
69	Specific Activity [micromol/min/mg]
1	Storage Stability
208	Substrates and Products (Substrate)
13	Subunits
351	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Application

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Application on EC 3.1.4.39 - alkylglycerophosphoethanolamine phosphodiesterase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

analysis

3 entries

diagnostics

Homo sapiens

-

lysoPLD assay can be applied to clinical laboratory testing. Serum lysoPLD activity in healthy female subjects is significantly higher than that in male subjects. It seems likely that lysoPLD and its product lysophosphatidic acid participate in female reproductive biology. lysoPLD assay method seems to be promising for laboratory testing because it allows easy handling of the samples

679257

drug development

4 entries

medicine

11 entries

molecular biology

Homo sapiens

-

is involved in the regulation of IL-8 and CD54 gene

665229

additional information

Rattus norvegicus

-

regulates cell growth, motility, and angiogenesis

665048

analysis

Bacillus cereus

-

fluorogenic substrates, potential in screening for inhibitors and for monitoring spatiotemporal changes in activity in cells

682231

analysis

Clostridium perfringens

-

fluorogenic substrates, potential in screening for inhibitors and for monitoring spatiotemporal changes in activity in cells

682231

analysis

Homo sapiens

-

the purified ATX protein is enzymatically active and biologically functional, offering a useful tool for further biological and structural studies of this important enzyme

714603

drug development

Homo sapiens

Q13822

ATX is one of the target molecules for cancer therapy, therefore the immuno-neutralization by an antibody which is able to recognize the catalytic site, or the low molecular weight chemical inhibitors based on structural biology should be a useful tool for prevention or treatment of tumor progression and metastasis

682694

drug development

Mammalia

-

to inhibit lysophosphatidic acid production in the blood. Inhibition of autotaxin/lysoPLD activity by small molecules could be an effective new therapeutic approach for cancer and possibly cardiovascular disease

681769

drug development

Homo sapiens

-

ATX is a target for cancer treatment

714038

drug development

Homo sapiens

-

the enzyme is a good target for small molecule inhibitors

730155

medicine

Streptomyces chromofuscus

-

promotes tumor cell motility, experimental metastasis, and angiogenesis

665628

medicine

Rattus norvegicus

-

stimulates cell proliferation, cell motility and angiogenesis

665800

medicine

Homo sapiens

-

survival factor, preventing serum-deprivation induced apoptosis in fibroblasts through extracellular activation of LPA signaling pathway

663885

medicine

Homo sapiens

-

tumor cell motility-stimulating factor

665229, 666223, 670114

medicine

Homo sapiens

-

tumor cell motility-stimulating factor, implicated in the progression of tumor

6, 663457

medicine

Mus musculus

-

tumor cell motility-stimulating factor, represents a potential target for cancer therapy

665507

medicine

Rattus norvegicus

-

inhibitors of autotaxin can be used as a therapy for the treatment of cancer

704477

medicine

Homo sapiens

-

the autotaxin-lysophosphatidic acid receptor axis is a rich therapeutic target in cancer

703104

medicine

Homo sapiens

-

autotaxin is an attractive target for the anticancer therapeutics that inhibit angiogenesis, invasion, and migration

714443

medicine

Homo sapiens

-

is an attractive target for cancer therapy

713665

medicine

Homo sapiens

Q13822

autotaxin gene expression is significantly higher in neoplastic endometrium compared with normal tissue. The expression of autotaxin is significantly elevated in type I endometrial cancer compared to type II, in premenopausal women and in patients affected either by obesity or diabetes

751460