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Literature summary for 3.1.4.39 extracted from

  • Saunders, L.P.; Cao, W.; Chang, W.C.; Albright, R.A.; Braddock, D.T.; De La Cruz, E.M.
    Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution (2011), J. Biol. Chem., 286, 30130-30141.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.39

Protein Variants

Protein Variants Comment Organism
T210A inactive mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ammonium chloride
-
 Homo sapiens
choline
-
 Homo sapiens
FTY720P binds apo-ATX and an ATX with bound FS-3/products complex, noncompetitive/mixed inhibition Homo sapiens
oleoyl-LPA inhibition of ATX pNP-TMP hydrolysis activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information steady-state, single-turnover, and transient kinetics, kinetic analysis and modeling, using artificial fluorescent substrate FS-3, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ two catalytic zinc ions in the active site Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information reaction mechanism of NBD-LPC hydrolysis, overview. Artificial substrates FS-3 and pNP-TMP are used for kinetic studies, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ATX
-
 Homo sapiens
autotaxin
-
 Homo sapiens
lysophospholipase D
-
 Homo sapiens

General Information

General Information Comment Organism
additional information Thr210 coordinates one of the two catalytic zinc ions and hydrogen bonds with the phosphate or sulfate in the active site. Kinetics of ATX depend strongly on the substrate identity, suggesting that ATX could display different kinetic profiles for the various in vivo substrates Homo sapiens
physiological function autotaxin is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine into lysophosphatidic acid, initiating signaling cascades leading to cancer metastasis, wound healing, and angiogenesis Homo sapiens