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Literature summary for 3.1.4.39 extracted from
- Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin (2009), J. Biol. Chem., 284, 14296-14302.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | inhibitors of autotaxin can be used as a therapy for the treatment of cancer | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293 cells | Rattus norvegicus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C194A | the mutant shows a specific activity similar to the wild type enzyme | Rattus norvegicus |
| C366A | the mutant shows a specific activity similar to the wild type enzyme | Rattus norvegicus |
| C413A | weakly active | Rattus norvegicus |
| C468A | the mutant shows a specific activity similar to the wild type enzyme | Rattus norvegicus |
| C513A | the mutant shows a specific activity similar to the wild type enzyme | Rattus norvegicus |
| C651A | the mutant shows a specific activity similar to the wild type enzyme | Rattus norvegicus |
| C666A | the mutant shows a specific activity similar to the wild type enzyme | Rattus norvegicus |
| C774A | the mutant shows a specific activity similar to the wild type enzyme | Rattus norvegicus |
| C784A | the mutant shows a specific activity similar to the wild type enzyme | Rattus norvegicus |
| C805A | weakly active | Rattus norvegicus |
| additional information | NPP2-(1-594) lacking the nuclease-like domain does not exhibit any lysophospholipase-D or nucleotide phosphodiesterase activities | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl-TMP + H2O | - |
Rattus norvegicus | 4-nitrophenol + TMP | - |
? |  |
| lysophosphatidylcholine + H2O | - |
Rattus norvegicus | lysophosphatidic acid + choline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| autotaxin | - |
Rattus norvegicus |
| lysophospholipase-D | - |
Rattus norvegicus |
| NPP2 | - |
Rattus norvegicus |
| nucleotide pyrophosphatase/phosphodiesterase 2 | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | autotoxin promotes metastasis and tumor growth | Rattus norvegicus |
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Release 2023.1 (January 2023)
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