Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.39 extracted from

  • Yukiura, H.; Hama, K.; Nakanaga, K.; Tanaka, M.; Asaoka, Y.; Okudaira, S.; Arima, N.; Inoue, A.; Hashimoto, T.; Arai, H.; Kawahara, A.; Nishina, H.; Aoki, J.
    Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish (2011), J. Biol. Chem., 286, 43972-43983.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.39

Cloned(Commentary)

Cloned (Comment) Organism
gene atx, DNA and amino acid sequence determination and analysis, recombinant expression in HEK-293 cells Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Danio rerio zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine ?
-
 ?
additional information Danio rerio AB zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
 gene atx
-
Danio rerio AB
-
 gene atx
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine Danio rerio ?
-
 ?
additional information zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine Danio rerio AB ?
-
 ?

Synonyms

Synonyms Comment Organism
ATX
-
 Danio rerio
autotaxin
-
 Danio rerio

General Information

General Information Comment Organism
malfunction knockdown of ATX in zebrafish embryos causes abnormal blood vessel formation. In ATX morphant embryos, the segmental arteries sprouted normally from the dorsal aorta but stalled in the mid-course resulting in aberrant vascular connection around the horizontal myoseptum Danio rerio
physiological function autotaxin is a multifunctional ecto-type phosphodiesterase that converts lysophospholipids such as lysophosphatidylcholine to lysophosphatidic acid by its lysophospholipase D activity. ATX has an essential role in embryonic blood vessel formation. Autotaxin is required for the development of intersegmental arteries in zebrafish Danio rerio