3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase

This is an abbreviated version!
For detailed information about alkylglycerophosphoethanolamine phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.39

Reaction

1-alkyl-sn-glycero-3-phosphoethanolamine
+
H2O
=
1-alkyl-sn-glycerol 3-phosphate
+
ethanolamine

Synonyms

More, glycerophosphodiesterase, autotaxin, PLD, lysophospholipase D, phosphodiesterase, alkylglycerophosphorylethanolamine, ATX, GDE1, autocrine motility factor, NPP2, lysoPLD, ATX/NPP2, LPLD, NPP-2, ENPP2, lysoPLD/NPP2, lyso-PLD, NPP2alpha, hATX, human autotaxin alpha, human autotaxin beta, ectonucleotide pyrophosphatase phosphodiesterase-2, lysoPLD autotaxin, nucleotide pyrophosphatase-phosphodiesterase, autotaxin beta, mATX, autotaxin/lysoPLD, human autotaxin, rhATX S48, mATXgamma, ATXgamma, autotaxin gamma, NPP2gamma, ectonucleotide pyrophosphatase/phosphodiesterase 2, GDE4, phosphodiesterase Ialpha/autotoxin, PD-Ialpha/ATX, (ecto)nucleotide pyrophosphatase/phosphodiesterase 2 [(E)NPP2], nucleotide phosphodiesterase/pyrophosphatase (NPP), autotaxin (ATX), ectonucleotide pyrophosphatase/phosphodiesterase, lysophospholipase-D, nucleotide pyrophosphatase/phosphodiesterase 2, ATX/lysoPLD, phosphodiesterase Ialpha, PD-Ialpha, ecto-nucleotide pyrophosphatase/phosphodiesterase-2, zATX, ENPP, Heminecrolysin, GDPD1, AtxB, GDE7, GDPD3

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase

Source Tissue

Source Tissue on EC 3.1.4.39 - alkylglycerophosphoethanolamine phosphodiesterase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
secrets the mature ATX
Manually annotated by BRENDA team
-
the enzyme is constitutively released from corneal tissues and/or ciliary body into the aqueous humor, with no injury-induced increase in release following freeze-wounding
Manually annotated by BRENDA team
-
corneal stromal cells and endothelial and epithelial cells, the enzyme is constitutively released from corneal tissues and/or ciliary body into the aqueous humor, with no injury-induced increase in release following freeze-wounding
Manually annotated by BRENDA team
-
embryonic spinal cord
Manually annotated by BRENDA team
-
LysoPLD activity is determined in culture medium from control cells or cells expressing V5-autotaxin (ATX)
Manually annotated by BRENDA team
Various concentrations of hATX S48 protein are exposed to HT-1080 cells and motile area is analyzed. hATX S48 protein also affects cell proliferation
Manually annotated by BRENDA team
-
Detection of lysophospholipase D/autotoxin (lysoPLD/ATX) antigen in the urine samples of patients with nephrotic syndrome, both with active and inactive disease states. LysoPLD/ATX antigen detection in the urine and its concentrations seem to be correlated with the total urinary protein concentrations
Manually annotated by BRENDA team
-
from E7.5 to E9.5, Enpp2 mRNA is abundantly expressed in the visceral endoderm cells
Manually annotated by BRENDA team
additional information