3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase
This is an abbreviated version!
For detailed information about alkylglycerophosphoethanolamine phosphodiesterase, go to the full flat file.
Word Map on EC 3.1.4.39
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3.1.4.39
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lysophosphatidic
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lysophosphatidylcholine
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phospholipid
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fibrosis
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lysophospholipids
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atx-lpa
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metastasis
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choline
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protein-coupled
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melanoma
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autocrine
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motility-stimulating
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ectoenzyme
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lpa-producing
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sphingosine
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analysis
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pruritus
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drug development
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ectonucleoside
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lpars
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e-npps
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motogenic
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lpa-induced
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medicine
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molecular biology
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lysophosphatidylserine
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ntpdases
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diagnostics
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diphosphohydrolase
- 3.1.4.39
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lysophosphatidic
- lysophosphatidylcholine
- phospholipid
- fibrosis
- lysophospholipids
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atx-lpa
- metastasis
- choline
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protein-coupled
- melanoma
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autocrine
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motility-stimulating
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ectoenzyme
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lpa-producing
- sphingosine
- analysis
- pruritus
- drug development
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ectonucleoside
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lpars
- e-npps
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motogenic
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lpa-induced
- medicine
- molecular biology
- lysophosphatidylserine
- ntpdases
- diagnostics
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diphosphohydrolase
Reaction
Synonyms
(ecto)nucleotide pyrophosphatase/phosphodiesterase 2 [(E)NPP2], ATX, ATX/lysoPLD, ATX/NPP2, AtxB, ATXgamma, autocrine motility factor, autotaxin, autotaxin (ATX), autotaxin beta, autotaxin gamma, autotaxin/lysoPLD, ecto-nucleotide pyrophosphatase/phosphodiesterase-2, ectonucleotide pyrophosphatase phosphodiesterase-2, ectonucleotide pyrophosphatase/phosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase 2, ENPP, ENPP2, GDE1, GDE4, GDE7, GDPD1, GDPD3, glycerophosphodiesterase, hATX, Heminecrolysin, human autotaxin, human autotaxin alpha, human autotaxin beta, LPLD, lyso-PLD, lysophospholipase D, lysophospholipase-D, lysoPLD, lysoPLD autotaxin, lysoPLD/NPP2, mATX, mATXgamma, More, NPP-2, NPP2, NPP2alpha, NPP2gamma, nucleotide phosphodiesterase/pyrophosphatase (NPP), nucleotide pyrophosphatase-phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase 2, PD-Ialpha, PD-Ialpha/ATX, phosphodiesterase Ialpha, phosphodiesterase Ialpha/autotoxin, phosphodiesterase, alkylglycerophosphorylethanolamine, PLD, rhATX S48, zATX
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3.1.4.39 alkylglycerophosphoethanolamine phosphodiesteraseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.1.4.39 - alkylglycerophosphoethanolamine phosphodiesterase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O
1-alkyl-sn-glycerol 3-phosphate + ethanolamine
1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-2-lyso-sn-glycero-3-phosphate + choline
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may play a role in the metabolism of platelet-activating factor
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?
1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycerol 3-phosphate + choline
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-
-
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?
1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycerol 3-phosphate + choline
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-
-
-
?
1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycerol 3-phosphate + choline
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-
-
-
?
1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycerol 3-phosphate + choline
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-
-
-
?
1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycerol 3-phosphate + choline
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16:0, 18:1 and 18:2-lysophosphatidylcholine are the predominant physiological substrates of the enzyme in rabbit aqueous humor
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-
?
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O
1-alkyl-sn-glycerol 3-phosphate + ethanolamine
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-
-
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?
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O
1-alkyl-sn-glycerol 3-phosphate + ethanolamine
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-
-
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r
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
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-
-
-
?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
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-
-
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?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
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bioactive phospholipid regulating a wide range of cellular responses
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?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
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present in the plasma
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-
?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
lysophospholipase D activity
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-
?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
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-
-
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?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
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lysophosphatidic acid is a bioactive lysophospholipid present in circulating blood
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?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
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lysophosphatidic acid is a bioactive phospholipid regulating a wide range of cellular responses
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?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
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-
-
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?
lysophosphatidylcholine + H2O
lysophosphatidic acid + choline
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-
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?
additional information
?
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zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine
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-
?
additional information
?
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the enzyme converts lysophospholipids such as lysophosphatidylcholine to lysophosphatidic acid
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-
?
additional information
?
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zATX preferably hydrolyzes LPC and lysophosphatidylethanolamine but does not efficiently hydrolyze lysophosphatidylserine, lysophosphatidylinositol or sphingosylphosphorylcholine
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-
?
additional information
?
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the enzyme is active on human macrophages, erythrocytes, Jurkat and HeLa cells, and on chicken embryo chorioallantoic membrane
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-
?
additional information
?
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activity implicated in a large variety of biological processes (during normal development and under pathological conditions). Developmental roles include adipogenesis, intestinal cell motility and neurite morphology, a contribution to disease is described for alzheimer's disease, chronic hepatitis C, multiple sclerosis, neuropathic pain, obesity, rheumatoid arthritis
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-
?
additional information
?
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the enzyme hydrolyzes extracellular lysophospholipids into the lipid mediator lysophosphatidic acid, a ligand for specific G protein-coupled receptors
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-
?
additional information
?
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Loxosceles sp.
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the enzyme hydrolyzes extracellular lysophospholipids into the lipid mediator lysophosphatidic acid, a ligand for specific G protein-coupled receptors
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-
?
additional information
?
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brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview
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-
?
additional information
?
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the enzyme converts lysophospholipids such as lysophosphatidylcholine to lysophosphatidic acid
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-
?
additional information
?
-
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the enzyme hydrolyzes extracellular lysophospholipids into the lipid mediator lysophosphatidic acid, a ligand for specific G protein-coupled receptors
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-
?
additional information
?
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brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview
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-
?
additional information
?
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the product lysophosphatidic acid mediates multiple biological functions
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?
additional information
?
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binding of ATX to activated platelets and lymphocytes in an integrin-dependent manner mediated by the consecutive cysteine-rich somatomedin-B-like, SMB, domains
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?
additional information
?
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heterotrimeric G protein subunits Galphaq and Gbeta1 have lysophospholipase D activity, choline production from lysoPAF by the purified FLAG-tagged Galphaq, overview. K52A, T186A, D205A, G48A and Q209L mutant forms of Galphaq show a significant reduction of lysoPLD activity, whereas G48V does not. The decrease of lysoPLD activity of G48A and Q209L is low
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-
?
additional information
?
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protein-protein interaction with proteins via the enzyme's SMB1 domain, which binds to the PDE domain. The enzyme binds to activated lymphocytes possibly involving an enzyme lymphocyte- and alpha4beta1-specific 458LDV460 motif. Autotaxin (ATX or ENPP2) is an ectonucleotide pyrophosphatase/phosphodiesterase that functions as a secreted lysophospholipase D to produce the multifunctional lipid mediator lysophosphatidic acid from more complex lysophospholipids
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-
?
additional information
?
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the enzyme hydrolyzes extracellular lysophospholipids into the lipid mediator lysophosphatidic acid, a ligand for specific G protein-coupled receptors
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-
?
