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3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase

This is an abbreviated version!
For detailed information about alkylglycerophosphoethanolamine phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.39

Reaction

1-alkyl-sn-glycero-3-phosphoethanolamine
+
H2O
=
1-alkyl-sn-glycerol 3-phosphate
 +
ethanolamine

Synonyms

(ecto)nucleotide pyrophosphatase/phosphodiesterase 2 [(E)NPP2], ATX, ATX/lysoPLD, ATX/NPP2, AtxB, ATXgamma, autocrine motility factor, autotaxin, autotaxin (ATX), autotaxin beta, autotaxin gamma, autotaxin/lysoPLD, ecto-nucleotide pyrophosphatase/phosphodiesterase-2, ectonucleotide pyrophosphatase phosphodiesterase-2, ectonucleotide pyrophosphatase/phosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase 2, ENPP, ENPP2, GDE1, GDE4, GDE7, GDPD1, GDPD3, glycerophosphodiesterase, hATX, Heminecrolysin, human autotaxin, human autotaxin alpha, human autotaxin beta, LPLD, lyso-PLD, lysophospholipase D, lysophospholipase-D, lysoPLD, lysoPLD autotaxin, lysoPLD/NPP2, mATX, mATXgamma, More, NPP-2, NPP2, NPP2alpha, NPP2gamma, nucleotide phosphodiesterase/pyrophosphatase (NPP), nucleotide pyrophosphatase-phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase 2, PD-Ialpha, PD-Ialpha/ATX, phosphodiesterase Ialpha, phosphodiesterase Ialpha/autotoxin, phosphodiesterase, alkylglycerophosphorylethanolamine, PLD, rhATX S48, zATX

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase

Expression

Expression on EC 3.1.4.39 - alkylglycerophosphoethanolamine phosphodiesterase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
autotaxin activity is unaffected by treatment with eicosapentaenoic acid and docosahexaenoic acid, and aspirin has no effect on any endpoint
-
enhanced enzyme expression in the inflamed mucosa from Crohn's disease and ulcerative colitis patients, the enzyme expression is remarkably higher in the actively inflamed mucosa than in the quiescent mucosa in the same patient
-
enzyme expression is up-regulated in obese mice in relationship with insulin resistance and impaired glucose tolerance
-
enzyme expression is up-regulated in obese patients in relationship with insulin resistance and impaired glucose tolerance
-
lipopolysaccharide induces autotaxin beta-isoform expression in THP-1 cells
-
lipopolysaccharides challenge induces ATX expression and release into the medium
-
no injury-induced increase in release following freeze-wounding
-
phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells
-
the concentration and enzyme activity of ATX are not affected by nerve injury
-