3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase

This is an abbreviated version!
For detailed information about alkylglycerophosphoethanolamine phosphodiesterase, go to the full flat file.

Word Map on EC 3.1.4.39

3.1.4.39

lysophosphatidic

lysophosphatidylcholine

phospholipid

fibrosis

lysophospholipids

atx-lpa

metastasis

choline

protein-coupled

melanoma

autocrine

motility-stimulating

ectoenzyme

lpa-producing

sphingosine

analysis

pruritus

drug development

ectonucleoside

lpars

e-npps

motogenic

lpa-induced

medicine

molecular biology

lysophosphatidylserine

ntpdases

diagnostics

diphosphohydrolase

Reaction

1-alkyl-sn-glycero-3-phosphoethanolamine

Synonyms

(ecto)nucleotide pyrophosphatase/phosphodiesterase 2 [(E)NPP2], ATX, ATX/lysoPLD, ATX/NPP2, AtxB, ATXgamma, autocrine motility factor, autotaxin, autotaxin (ATX), autotaxin beta, autotaxin gamma, autotaxin/lysoPLD, ecto-nucleotide pyrophosphatase/phosphodiesterase-2, ectonucleotide pyrophosphatase phosphodiesterase-2, ectonucleotide pyrophosphatase/phosphodiesterase, ectonucleotide pyrophosphatase/phosphodiesterase 2, ENPP, ENPP2, GDE1, GDE4, GDE7, GDPD1, GDPD3, glycerophosphodiesterase, hATX, Heminecrolysin, human autotaxin, human autotaxin alpha, human autotaxin beta, LPLD, lyso-PLD, lysophospholipase D, lysophospholipase-D, lysoPLD, lysoPLD autotaxin, lysoPLD/NPP2, mATX, mATXgamma, More, NPP-2, NPP2, NPP2alpha, NPP2gamma, nucleotide phosphodiesterase/pyrophosphatase (NPP), nucleotide pyrophosphatase-phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase 2, PD-Ialpha, PD-Ialpha/ATX, phosphodiesterase Ialpha, phosphodiesterase Ialpha/autotoxin, phosphodiesterase, alkylglycerophosphorylethanolamine, PLD, rhATX S48, zATX

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.4 Phosphoric-diester hydrolases

3.1.4.39 alkylglycerophosphoethanolamine phosphodiesterase

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Results	in table
7	Activating Compound
21	AA Sequence
24	Application
1	CAS Registry Number
38	Cloned(Commentary)
7	Crystallization (Commentary)
901	Disease/ Diagnostics
9	Expression
64	General Information
2	General Stability
54	IC50 Value
243	Inhibitors
2	kcat/KM [mM/s]
71	Ki Value [mM]
46	KM Value [mM]
50	Localization
58	Metals/Ions
27	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
335	Organism
5	Pathway
61	PDB ID
15	pH Optimum
4	pH Range
17	Posttranslational Modification
75	Protein Variants
18	Purification (Commentary)
1	Reaction
12	Reaction Type
113	Reference
161	Source Tissue
69	Specific Activity [micromol/min/mg]
1	Storage Stability
208	Substrates and Products (Substrate)
13	Subunits
351	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.1.4.39 - alkylglycerophosphoethanolamine phosphodiesterase

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bFGF

Homo sapiens

induces a 1.9fold higher ATX mRNA expression

Co2+

extracellular enzyme

EGF

induces a 2.3fold higher ATX mRNA expression

665229

heparin

2 entries

IL-6

Homo sapiens

induces a marked increase in ATX mRNA expression

665229

integrins

Homo sapiens

ATX activity against exogenously provided and cell-associated substrates is increased by integrin binding

715637