Cloned (Comment) | Organism |
---|---|
recombinant expression of GDE1 in COS-7 cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus | |
EDTA | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview | ? | - |
? | |
additional information | Mus musculus C57BL/6 | brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O | - |
Mus musculus | 1-alkyl-sn-glycerol 3-phosphate + ethanolamine | - |
? | |
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O | - |
Mus musculus C57BL/6 | 1-alkyl-sn-glycerol 3-phosphate + ethanolamine | - |
? | |
additional information | brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview | Mus musculus | ? | - |
? | |
additional information | brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview | Mus musculus C57BL/6 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GDE1 | - |
Mus musculus |
glycerophosphodiesterase | - |
Mus musculus |
lysophospholipase D | - |
Mus musculus |
lysoPLD | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | GDE1 has a weak activity to generate N-palmitoylethanolamine from its corresponding 1-alkenyl-2-hydroxy-glycero-3-phospho(N-acyl)ethanolamines, suggesting that this enzyme is at least in part responsible for the lysophospholipase D activity in mouse brain | Mus musculus |