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Literature summary for 3.1.4.39 extracted from

  • Clair, T.; Koh, E.; Ptaszynska, M.; Bandle, R.W.; Liotta, L.A.; Schiffmann, E.; Stracke, M.L.
    L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin (2005), Lipids Health Dis., 4, DOI:10.1186/1476-511X-4-5.
No PubMed abstract available
Search for more literature for 3.1.4.39

Application

Application Comment Organism
medicine tumor cell motility-stimulating factor Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 0.5 mM Homo sapiens
D-histidine 15 mM, 75% inhibition Homo sapiens
EDTA 10-20 mM Homo sapiens
L-histidine 15-20 mM, noncompetitive, 75% inhibition, inhibition can be reversed by 20fold lower concentrations of zinc or cobalt salts Homo sapiens
L-histidine amide 15 mM, 20% inhibition Homo sapiens
L-histidine methylester 15 mM, 65% inhibition Homo sapiens
N-methyl-L-histidine 15 mM, 30% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.47
-
 lysophosphatidylcholine in presence of 0.25 mM Zn2+ plus 10 mM L-histidine Homo sapiens
0.49
-
 lysophosphatidylcholine
-
 Homo sapiens
0.55
-
 lysophosphatidylcholine in presence of 0.25 mM Zn2+ Homo sapiens
0.66
-
 lysophosphatidylcholine in presence of 10 mM L-histidine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
prepared from a Vaccinia viral lysate through the concanavalin A-agarose step Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lysophosphatidylcholine + H2O
-
 Homo sapiens lysophosphatidic acid + choline
-
 ?

Synonyms

Synonyms Comment Organism
ATX
-
 Homo sapiens
autotaxin
-
 Homo sapiens
LPLD
-
 Homo sapiens
lysophospholipase D
-
 Homo sapiens
NPP-2
-
 Homo sapiens