Reference on EC 2.7.11.18 - myosin-light-chain kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q15746)
Deloukas, P.; Matthews, L.H.; Ashurst, J.; Burton, J.; Gilbert, J.G.; et al.
The DNA sequence and comparative analysis of human chromosome 20
Nature
414
865-871
2001
Homo sapiens (Q9H1R3)
Kemp, B.E.; Parker, M.W.; Hu, S.; Tiganis, T.; House, C.
Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity
Trends Biochem. Sci.
19
440-444
1994
Mammalia
Kemp, B.E.; Pearson, R.B.; House, M.
Pseudosubstrate-based peptide inhibitors
Methods Enzymol.
201
287-304
1991
eukaryota
Davis, J.S.; Hassanzadeh, S.; Winitsky, S.; Lin, H.; Satorius, C.; Vemuri, R.; Aletras, A.H.; Wen, H.; Epstein, N.D.
The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation
Cell
107
631-641
2001
Oryctolagus cuniculus (P07313), Homo sapiens (Q9H1R3), Homo sapiens
Herring, B.P.; Stull, J.T.; Gallagher, P.J.
Domain characterization of rabbit skeletal muscle myosin light chain kinase
J. Biol. Chem.
265
1724-1730
1990
Oryctolagus cuniculus (P07313), Oryctolagus cuniculus
Ikura, M.; Clore, G.M.; Gronenborn, A.M.; Zhu, G.; Klee, C.B.; Bax, A.
Solution structure of a calmodulin-target peptide complex by multidimensional NMR
Science
256
632-638
1992
Oryctolagus cuniculus (P07313)
Takio, K.; Blumenthal, D.K.; Edelman, A.M.; Walsh, K.A.; Krebs, E.G.; Titani, K.
Amino acid sequence of an active fragment of rabbit skeletal muscle myosin light chain kinase
Biochemistry
24
6028-6037
1985
Oryctolagus cuniculus (P07313), Oryctolagus cuniculus
Takio, K.; Blumenthal, D.K.; Walsh, K.A.; Titani, K.; Krebs, E.G.
Amino acid sequence of rabbit skeletal muscle myosin light chain kinase
Biochemistry
25
8049-8057
1986
Oryctolagus cuniculus (P07313), Oryctolagus cuniculus
Collinge, M.; Matrisian, P.E.; Zimmer, W.E.; Shattuck, R.L.; Lukas, T.J.; Van Eldik, L.J.; Watterson, D.M.
Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene
Mol. Cell. Biol.
12
2359-2371
1992
Gallus gallus (P11799), Gallus gallus
Guerriero, V.Jr.; Russo, M.A.; Olson, N.J.; Putkey, J.A.; Means, A.R.
Domain organization of chicken gizzard myosin light chain kinase deduced from a cloned cDNA
Biochemistry
25
8372-8381
1986
Gallus gallus (P11799), Gallus gallus
Olson, N.J.; Pearson, R.B.; Needleman, D.S.; Hurwitz, M.Y.; Kemp, B.E.; Means, A.R.
Regulatory and structural motifs of chicken gizzard myosin light chain kinase
Proc. Natl. Acad. Sci. USA
87
2284-2288
1990
Gallus gallus (P11799), Gallus gallus
Shoemaker, M.O.; Lau, W.; Shattuck, R.L.; Kwiatkowski, A.P.; Matrisian, P.E.; Guerra-Santos, L.; Wilson, E.; Lukas, T.J.; Van Eldik, L.J.; Watterson, D.M.
Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity
J. Cell Biol.
111
1107-1125
1990
Gallus gallus (P11799), Gallus gallus
Watterson, D.M.; Collinge, M.; Lukas, T.J.; Van Eldik, L.J.; Birukov, K.G.; Stepanova, O.V.; Shirinsky, V.P.
Multiple gene products are produced from a novel protein kinase transcription region
FEBS Lett.
373
217-220
1995
Gallus gallus (P11799)
Yoshikai, S.; Ikebe, M.
Molecular cloning of the chicken gizzard telokin gene and cDNA
Arch. Biochem. Biophys.
299
242-247
1992
Gallus gallus (P11799), Gallus gallus
Roush, C.L.; Kennelly, P.J.; Glaccum, M.B.; Helfman, D.M.; Scott, J.D.; Krebs, E.G.
Isolation of the cDNA encoding rat skeletal muscle myosin light chain kinase. Sequence and tissue distribution
J. Biol. Chem.
263
10510-10516
1988
Rattus norvegicus (P20689)
Tan, J.L.; Spudich, J.A.
Characterization and bacterial expression of the Dictyostelium myosin light chain kinase cDNA. Identification of an autoinhibitory domain
J. Biol. Chem.
266
16044-16049
1991
Dictyostelium discoideum (P25323)
Tan, J.L.; Spudich, J.A.
Dictyostelium myosin light chain kinase. Purification and characterization
J. Biol. Chem.
265
13818-13824
1990
Dictyostelium discoideum (P25323), Dictyostelium discoideum Ax-3 (P25323)
Gallagher, P.J.; Herring, B.P.; Griffin, S.A.; Stull, J.T.
Molecular characterization of a mammalian smooth muscle myosin light chain kinase [published erratum appears in J Biol Chem 1992 May 5;267(13):9450]
J. Biol. Chem.
266
23936-23944
1991
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Oryctolagus cuniculus (P29294), Rattus norvegicus
Gallagher, P.J.; Herring, B.P.
The carboxyl terminus of the smooth muscle myosin light chain kinase is expressed as an independent protein, telokin
J. Biol. Chem.
266
23945-23952
1991
Oryctolagus cuniculus (P29294)
Garcia, J.G.N.; Lazar, V.; Gilbert-McClain, L.I.; Gallagher, P.J.; Verin, A.D.
Myosin light chain kinase in endothelium: molecular cloning and regulation
Am. J. Respir. Cell Mol. Biol.
16
489-494
1997
Bos taurus, Homo sapiens, Homo sapiens (Q15746)
Lazar, V.; Garcia, J.G.
A single human myosin light chain kinase gene (MLCK; MYLK)
Genomics
57
256-267
1999
Homo sapiens (Q15746), Homo sapiens
Potier, M.C.; Chelot, E.; Pekarsky, Y.; Gardiner, K.; Rossier, J.; Turnell, W.G.
The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21
Genomics
29
562-570
1995
Homo sapiens (Q15746), Homo sapiens
Watterson, D.M.; Schavocky, J.P.; Guo, L.; Weiss, C.; Chlenski, A.; Shirinsky, V.P.; Van Eldik, L.J.; Haiech, J.
Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker
J. Cell. Biochem.
75
481-491
1999
Homo sapiens (Q15746), Homo sapiens
Kobayashi, H.; Inoue, A.; Mikawa, T.; Kuwayama, H.; Hotta, Y.; Masaki, T.; Ebashi, S.
Isolation of cDNA for bovine stomach 155 kDa protein exhibiting myosin light chain kinase activity
J. Biochem.
112
786-791
1992
Bos taurus (Q28824), Bos taurus
Pires, E.; Perry, S.V.; Thomas, M.A.W.
Myosin light-chain kinase, a new enzyme from striated muscle
FEBS Lett.
41
292-296
1974
Oryctolagus cuniculus
Pires, E.M.V.; Perry, S.V.
Purification and properties of myosin light-chain kinase from fast skeletal muscle
Biochem. J.
167
137-146
1977
Oryctolagus cuniculus
Nagamoto, H.; Yagi, K.
Properties of myosin light chain kinase prepared from rabbit skeletal muscle by an improved method
J. Biochem.
95
1119-1130
1984
Oryctolagus cuniculus
Yang, H.H.; Boxer, L.A.
Purification of myosin light chain kinase from rabbit polymorphonuclear leukocytes
Pediatr. Res.
15
229-234
1981
Oryctolagus cuniculus
Hathaway, D.R.; Adelstein, R.S.
Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity
Proc. Natl. Acad. Sci. USA
76
1653-1657
1979
Homo sapiens
Serventi, I.M.; Coffee, C.J.
Characterization of myosin light-chain kinase from bovine adrenal medulla
Arch. Biochem. Biophys.
245
379-388
1986
Bos taurus
Walsh, M.P.; Hinkins, S.; Flink, I.L.; Hartshorne, D.J.
Bovine stomach myosin light chain kinase: purification, characterization, and comparison with the turkey gizzard enzyme
Biochemistry
21
6890-6896
1982
Bos taurus, Gallus gallus, Meleagris gallopavo
Walsh, M.P.; Vallet, B.; Autric, F.; Demaille, J.G.
Purification and characterization of bovine cardiac calmodulin-dependent myosin light chain kinase
J. Biol. Chem.
254
12136-12144
1979
Bos taurus
Wolf, H.; Hofmann, F.
Purification of myosin light chain kinase from bovine cardiac muscle
Proc. Natl. Acad. Sci. USA
77
5852-5855
1980
Bos taurus
Bartelt, D.C.; Moroney, S.; Wolff, D.J.
Purification, characterization and substrate specificity of calmodulin-dependent myosin light-chain kinase from bovine brain
Biochem. J.
247
747-756
1987
Bos taurus
Yamazaki, K.; Itoh, K.; Sobue, K.; Mori, T.; Shibata, N.
Purification of caldesmon and myosin light chain (MLC) kinase from arterial smooth muscle: comparisons with gizzard caldesmon and MLC kinase
J. Biochem.
101
1-9
1987
Bos taurus, Gallus gallus
Rogers, J.C.; Williams, D.L.
Kaempferol inhibits myosin light chain kinase
Biochem. Biophys. Res. Commun.
164
419-425
1989
Bos taurus
Pato, M.D.; Lye, S.J.; Kerc, E.
Purification and characterization of pregnant sheep myometrium myosin light chain kinase
Arch. Biochem. Biophys.
287
24-32
1991
Ovis aries, Homo sapiens, Meleagris gallopavo
Higashi, K.; Fukunaga, K.; Matsui, K.; Maeyama, M.; Miyamoto, E.
Purification and characterization of myosin light-chain kinase from porcine myometrium and its phosphorylation and modulation by cyclic AMP-dependent protein kinase
Biochim. Biophys. Acta
747
232-240
1983
Sus scrofa
Bissonnette, M.; Kuhn, D.; de Lanerolle, P.
Purification and characterization of myosin light-chain kinase from the rat pancreas
Biochem. J.
258
739-747
1989
Rattus norvegicus
Jinsart, W.; Ternai, B.; Polya, G.M.
Inhibition of myosin light chain kinase, cAMP-dependent protein kinase, protein kinase C and of plant Ca(2+)-dependent protein kinase by anthraquinones
Biol. Chem. Hoppe-Seyler
373
903-910
1992
Gallus gallus
Adelstein, R.S.; Klee, C.B.
Purification and characterization of smooth muscle myosin light chain kinase
J. Biol. Chem.
256
7501-7509
1981
Meleagris gallopavo
Adelstein, R.S.; Klee, C.B.
Purification of smooth muscle myosin light-chain kinase
Methods Enzymol.
85
298-308
1982
Homo sapiens, Meleagris gallopavo
-
Conti, M.A.; Adelstein, R.S.
Purification and properties of myosin light chain kinases
Methods Enzymol.
196
34-47
1991
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Meleagris gallopavo, Rattus norvegicus, Sus scrofa
Nunnally, M.H.; Rybicki, S.B.; Stull, J.T.
Characterization of chicken skeletal muscle myosin light chain kinase. Evidence for muscle-specific isozymes
J. Biol. Chem.
260
1020-1026
1985
Gallus gallus, Oryctolagus cuniculus
Leachman, S.A.; Gallagher, P.J.; Herring, B.P.; McPhaul, M.J.; Stull, J.T.
Biochemical properties of chimeric skeletal and smooth muscle myosin light chain kinases
J. Biol. Chem.
267
4930-4938
1992
Gallus gallus
Bailin, G.
Structure and function of a calmodulin-dependent smooth muscle myosin light chain kinase
Experientia
40
1185-1188
1984
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Meleagris gallopavo
Sellers, J.R.; Harvey, E.V.
Purification of myosin light chain kinase from Limulus muscle
Biochemistry
23
5821-5826
1984
Limulus sp.
Ikebe, M.; Reardon, S.; Fay, F.S.
Primary structure required for the inhibition of smooth muscle myosin light chain kinase
FEBS Lett.
312
245-248
1992
Meleagris gallopavo
Jinsart, W.; Ternai, B.; Polya, G.M.
Inhibition of wheat embryo calcium-dependent protein kinase and avian myosin light chain kinase by flavonoids and related compounds
Biol. Chem. Hoppe-Seyler
372
819-827
1991
Gallus gallus
Nakanishi, S.; Kakita, S.; Takahashi, I.; Kawahara, K.; Tsukada, E.; Sano, T.; Yamada, K.; Yoshida, M.; Kase, H.; Matsuda, Y.; Hashimoto, Y.; Nonomura, Y.
Wortmannin, a microbial product inhibitor of myosin light chain kinase
J. Biol. Chem.
267
2157-2163
1992
Gallus gallus
Kigoshi, T.; Uchida, K.; Kaneko, M.; Iwasaki, R.; Nakano, S.; Azukizawa, S.; Morimoto, S.
Direct inhibition of smooth muscle myosin light chain kinase by arachidonic acid in a purified system
Biochem. Biophys. Res. Commun.
171
369-374
1990
Meleagris gallopavo
Higashihara, M.
Inhibition of myosin light chain kinase by amiloride
Biochem. Biophys. Res. Commun.
162
1253-1259
1989
Meleagris gallopavo
Nakanishi, S.; Ando, K.; Kawamoto, I.; Matsuda, Y.
MS-347a, a new inhibitor of myosin light chain kinase from Aspergillus sp. KY52178
J. Antibiot.
46
1775-1781
1989
Gallus gallus
-
Jinsart, W.; Ternai, B.; Polya, G.M.
Inhibition and activation of wheat embryo calcium-dependent protein kinase and inhibition of avian myosin light chain kinase by long chain aliphatic amphiphiles
Plant Sci.
78
165-175
1991
Gallus gallus
-
Stull, J.T.; Nunnally, M.H.; Michnoff, C.H in
Calmoduline-dependent protein kinases
The Enzymes, 3rd. Ed. (Boyer, P. D. , Krebs, E. G. , eds. )
17
113-166
1986
Bos taurus, Canis lupus familiaris, Cavia porcellus, Gallus gallus, Homo sapiens, Meleagris gallopavo, Rattus norvegicus
-
Verin, A.D.; Gilbert-McClain, L.I.; Patterson, C.E.; Garcia, J.G.N.
Biochemical regulation of the nonmuscle myosin light chain kinase isoform in bovine endothelium
Am. J. Respir. Cell Mol. Biol.
19
767-776
1998
Bos taurus, Homo sapiens
Fujita, K.; Ye, L.H.; Sato, M.; Okagaki, T.; Nagamachi, Y.; Kohama, K.
Myosin light chain kinase from skeletal muscle regulates an ATP-dependent interaction between actin and myosin by binding to actin
Mol. Cell. Biochem.
190
85-90
1999
Gallus gallus
Okagaki, T.; Ye, L.H.; Samizo, K.; Tanaka, T.; Kohama, K.
Inhibitory effect of the catalytic domain of myosin light chain kinase on actin-myosin interaction: insight into the mode of inhibition
J. Biochem.
125
1055-1060
1999
Gallus gallus
Okagaki, T.; Hayakawa, K.; Samizo, K.; Kohama, K.
Inhibition of the ATP-dependent interaction of actin and myosin by the catalytic domain of the myosin light chain kinase of smooth muscle: possible involvement in smooth muscle relaxation
J. Biochem.
125
619-626
1999
Gallus gallus
Hayakawa, K.; Okagaki, T.; Ye, L.H.; Samizo, K.; Higashi-Fujime, S.; Takagi, T.; Kohama, K.
Characterization of the myosin light chain kinase from smooth muscle as an actin-binding protein that assembles actin filaments in vitro
Biochim. Biophys. Acta
1450
12-24
1999
Gallus gallus
Sobieszek, A.; Andruchov, O.Y.; Nieznanski, K.
Kinase-related protein (telokin) is phosphorylated by smooth-muscle myosin light-chain kinase and modulates the kinase activity
Biochem. J.
328
425-430
1997
Gallus gallus
-
Edwards, R.A.; Walsh, M.P.; Sutherland, C.; Vogel, H.J.
Activation of calcineurin and smooth muscle myosin light chain kinase by Met-to-Leu mutants of calmodulin
Biochem. J.
331
149-152
1998
Gallus gallus
-
Sobieszek, A.; Borkowski, J.; Babiychuk, V.S.
Purification and characterization of a smooth muscle myosin light chain kinase-phosphatase complex
J. Biol. Chem.
272
7034-7041
1997
Gallus gallus
Van Lierop, J.E.; Wilson, D.P.; Davis, J.P.; Tikunova, S.; Sutherland, C.; Walsh, M.P.; Johnson, J.D.
Activation of smooth muscle myosin light chain kinase by calmodulin. Role of Lys30 and Gly40
J. Biol. Chem.
277
6550-6558
2002
Gallus gallus, Rattus norvegicus
Champagne, M.B.; Edwards, K.A.; Erickson, H.P.; Kiehart, D.P.
Drosophila stretchin-MLCK is a novel member of the titin/myosin light chain kinase family
J. Mol. Biol.
300
759-777
2000
Drosophila melanogaster
Sanders, L.C.; Matsumura, F.; Bokoch, G.M.; de Lanerolle, P.
Inhibition of myosin light chain kinase by p21-activated kinase
Science
283
2083-2085
1999
Oncorhynchus mykiss
Gao, Z.H.; Zhi, G.; Herring, B.P.; Moomaw, C.; Deogny, L.; Slaughter, C.A.; Stull, J.T.
Photoaffinity labeling of a peptide substrate to myosin light chain kinase
J. Biol. Chem.
270
10125-10135
1995
Oryctolagus cuniculus
Toeroek, K.; Cowley, D.J.; Brandmeier, B.D.; Howell, S.; Aitken, A.; Trentham, D.R.
Inhibition of calmodulin-activated smooth-muscle myosin light-chain kinase by calmodulin-binding peptides and fluorescent (phosphodiesterase-activating) calmodulin derivatives
Biochemistry
37
6188-6198
1998
Sus scrofa
Lin, P.; Luby-Phelps, K.; Stull, J.T.
Properties of filament-bound myosin light chain kinase
J. Biol. Chem.
274
5987-5994
1999
Oryctolagus cuniculus
Padre, R.C.; Stull, J.T.
Conformational requirements for Ca2+/calmodulin binding and activation of myosin light chain kinase
FEBS Lett.
472
148-152
2000
Oryctolagus cuniculus
Smith, L.; Parizi-Robinson, M.; Zhu, M.S.; Zhi, G.; Fukui, R.; Kamm, K.E.; Stull, J.T.
Properties of long myosin light chain kinase binding to F-actin in vitro and in vivo
J. Biol. Chem.
277
35597-35604
2002
Gallus gallus
Dudek, S.M.; Birukov, K.G.; Zhan, X.; Garcia, J.G.N.
Novel interaction of cortactin with endothelial cell myosin light chain kinase
Biochem. Biophys. Res. Commun.
298
511-519
2002
Homo sapiens
Gao, Y.; Kawano, K.; Yoshiyama, S.; Kawamichi, H.; Wang, X.; Nakamura, A.; Kohama, K.
Myosin light chain kinase stimulates smooth muscle myosin ATPase activity by binding to the myosin heads without phosphorylating the myosin light chain
Biochem. Biophys. Res. Commun.
305
16-21
2003
Bos taurus
Yanase, M.; Ikeda, H.; Ogata, I.; Matsui, A.; Noiri, E.; Tomiya, T.; Arai, M.; Inoue, Y.; Tejima, K.; Nagashima, K.; Nishikawa, T.; Shibata, M.; Ikebe, M.; Rojkind, M.; Fujiwara, K.
Functional diversity between Rho-kinase- and MLCK-mediated cytoskeletal actions in a myofibroblast-like hepatic stellate cell line
Biochem. Biophys. Res. Commun.
305
223-228
2003
Rattus norvegicus
Grimm, M.; Haas, P.; Willipinski-Stapelfeldt, B.; Zimmermann, W.H.; Rau, T.; Pantel, K.; Weyand, M.; Eschenhagen, T.
Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium
Cardiovasc. Res.
65
211-220
2005
Homo sapiens
Deng, M.; Williams, C.J.; Schultz, R.M.
Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarity
Dev. Biol.
278
358-366
2005
Mus musculus
Kudryashov, D.S.; Stepanova, O.V.; Vilitkevich, E.L.; Nikonenko, T.A.; Nadezhdina, E.S.; Shanina, N.A.; Lukas, T.J.; Van Eldik, L.J.; Watterson, D.M.; Shirinsky, V.P.
Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain
Exp. Cell Res.
298
407-417
2004
Gallus gallus
Dulyaninova, N.G.; Bresnick, A.R.
The long myosin light chain kinase is differentially phosphorylated during interphase and mitosis
Exp. Cell Res.
299
303-314
2004
Oryctolagus cuniculus, Homo sapiens
Geguchadze, R.; Zhi, G.; Lau, K.S.; Isotani, E.; Persechini, A.; Kamm, K.E.; Stull, J.T.
Quantitative measurements of Ca(2+)/calmodulin binding and activation of myosin light chain kinase in cells
FEBS Lett.
557
121-124
2004
Homo sapiens
Adachi, T.; Stafford, S.; Kayaba, H.; Chihara, J.; Alam, R.
Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner
J. Allergy Clin. Immunol.
111
113-116
2003
Homo sapiens
Tokumitsu, H.; Hatano, N.; Inuzuka, H.; Ishikawa, Y.; Uyeda, T.Q.; Smith, J.L.; Kobayashi, R.
Regulatory mechanism of Dictyostelium myosin light chain kinase A
J. Biol. Chem.
279
42-50
2004
Dictyostelium discoideum (P25323)
Clayburgh, D.R.; Rosen, S.; Witkowski, E.D.; Wang, F.; Blair, S.; Dudek, S.; Garcia, J.G.; Alverdy, J.C.; Turner, J.R.
A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability
J. Biol. Chem.
279
55506-55513
2004
Homo sapiens (Q15746)
Wadgaonkar, R.; Nurmukhambetova, S.; Zaiman, A.L.; Garcia, J.G.
Mutation analysis of the non-muscle myosin light chain kinase (MLCK) deletion constructs on CV1 fibroblast contractile activity and proliferation
J. Cell. Biochem.
88
623-634
2003
Homo sapiens
Wadgaonkar, R.; Linz-McGillem, L.; Zaiman, A.L.; Garcia, J.G.
Endothelial cell myosin light chain kinase (MLCK) regulates TNFalpha-induced NFkappaB activity
J. Cell. Biochem.
94
351-364
2005
Homo sapiens
Wadgaonkar, R.; Dudek, S.M.; Zaiman, A.L.; Linz-McGillem, L.; Verin, A.D.; Nurmukhambetova, S.; Romer, L.H.; Garcia, J.G.
Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium
J. Cell. Biochem.
95
849-858
2005
Homo sapiens
Tinsley, J.H.; Yuan, S.Y.; Wilson, E.
Isoform-specific knockout of endothelial myosin light chain kinase: closing the gap on inflammatory lung disease
Trends Pharmacol. Sci.
25
64-66
2004
Homo sapiens, Mus musculus
Zhu, H.Q.; Wang, Y.; Hu, R.L.; Ren, B.; Zhou, Q.; Jiang, Z.K.; Gui, S.Y.
Distribution and expression of non-muscle myosin light chain kinase in rabbit livers
World J. Gastroenterol.
9
2715-2719
2003
Homo sapiens, Oryctolagus cuniculus
Herring, B.P.; El-Mounayri, O.; Gallagher, P.J.; Yin, F.; Zhou, J.
Regulation of and telokin expression in smooth muscle tissues
Am. J. Physiol.
291
C817-C827
2006
Mus musculus
Niggli, V.; Schmid, M.; Nievergelt, A.
Differential roles of Rho-kinase and myosin light chain kinase in regulating shape, adhesion, and migration of HT1080 fibrosarcoma cells
Biochem. Biophys. Res. Commun.
343
602-608
2006
Homo sapiens
Dudnakova, T.V.; Stepanova, O.V.; Dergilev, K.V.; Chadin, A.V.; Shekhonin, B.V.; Watterson, D.M.; Shirinsky, V.P.
Myosin light chain kinase colocalizes with nonmuscle myosin IIB in myofibril precursors and sarcomeric Z-lines of cardiomyocytes
Cell Motil. Cytoskeleton
63
375-383
2006
Gallus gallus, Homo sapiens
Yang, C.X.; Chen, H.Q.; Chen, C.; Yu, W.P.; Zhang, W.C.; Peng, Y.J.; He, W.Q.; Wei, D.M.; Gao, X.; Zhu, M.S.
Microfilament-binding properties of N-terminal extension of the isoform of smooth muscle long myosin light chain kinase
Cell Res.
16
367-376
2006
Oryctolagus cuniculus
Gu, L.Z.; Hu, W.Y.; Antic, N.; Mehta, R.; Turner, J.R.; de Lanerolle, P.
Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells
Eur. J. Cancer
42
948-957
2006
Mus musculus, Rattus norvegicus
Behling-Kelly, E.; McClenahan, D.; Kim, K.S.; Czuprynski, C.J.
Viable "Haemophilus somnus" induces myosin light-chain kinase-dependent decrease in brain endothelial cell monolayer resistance
Infect. Immun.
75
4572-4581
2007
Bos taurus
Zhu, H.; Zhang, X.; Zuo, L.; Zhou, Q.; Gui, S.; Wei, W.; Wang, Y.
Expression of myosin light chain kinase in kidney of streptozotocin-induced diabetic rats
Int. J. Mol. Sci.
7
510-518
2006
Rattus norvegicus
-
Ryder, J.W.; Lau, K.S.; Kamm, K.E.; Stull, J.T.
Enhanced skeletal muscle contraction with myosin light chain phosphorylation by a calmodulin-sensing kinase
J. Biol. Chem.
282
20447-20454
2007
Oryctolagus cuniculus
Connell, L.E.; Helfman, D.M.
Myosin light chain kinase plays a role in the regulation of epithelial cell survival
J. Cell Sci.
119
2269-2281
2006
Mus musculus
Seguchi, O.; Takashima, S.; Yamazaki, S.; Asakura, M.; Asano, Y.; Shintani, Y.; Wakeno, M.; Minamino, T.; Kondo, H.; Furukawa, H.; Nakamaru, K.; Naito, A.; Takahashi, T.; Ohtsuka, T.; Kawakami, K.; Isomura, T.; Kitamura, S.; Tomoike, H.; Mochizuki, N.; Kitakaze, M.
A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart
J. Clin. Invest.
117
2812-2824
2007
Danio rerio, Homo sapiens
Afonso, P.V.; Ozden, S.; Prevost, M.C.; Schmitt, C.; Seilhean, D.; Weksler, B.; Couraud, P.O.; Gessain, A.; Romero, I.A.; Ceccaldi, P.E.
Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization
J. Immunol.
179
2576-2583
2007
Homo sapiens
Tokuoka, H.; Goda, Y.
Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons
J. Neurosci.
26
11606-11614
2006
Rattus norvegicus
Shimizu, S.; Yoshida, T.; Wakamori, M.; Ishii, M.; Okada, T.; Takahashi, M.; Seto, M.; Sakurada, K.; Kiuchi, Y.; Mori, Y.
Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells
J. Physiol.
570
219-235
2006
Homo sapiens (Q15746), Homo sapiens (Q9H1R3), Homo sapiens
Blair, S.A.; Kane, S.V.; Clayburgh, D.R.; Turner, J.R.
Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
Lab. Invest.
86
191-201
2006
Homo sapiens
Lucero, A.; Stack, C.; Bresnick, A.R.; Shuster, C.B.
A global, myosin light chain kinase-dependent increase in myosin II contractility accompanies the metaphase-anaphase transition in sea urchin eggs
Mol. Biol. Cell
17
4093-4104
2006
Lytechinus pictus
Lamprecht, R.; Margulies, D.S.; Farb, C.R.; Hou, M.; Johnson, L.R.; LeDoux, J.E.
Myosin light chain kinase regulates synaptic plasticity and fear learning in the lateral amygdala
Neuroscience
139
821-829
2006
Rattus norvegicus
Reynoso, R.; Perrin, R.M.; Breslin, J.W.; Daines, D.A.; Watson, K.D.; Watterson, D.M.; Wu, M.H.; Yuan, S.
A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns
Shock
28
589-595
2007
Mus musculus
Mizuno, Y.; Isotani, E.; Huang, J.; Ding, H.; Stull, J.T.; Kamm, K.E.
Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo
Am. J. Physiol. Cell Physiol.
295
C358-C364
2008
Mus musculus
Injeti, E.R.; Sandoval, R.J.; Williams, J.M.; Smolensky, A.V.; Ford, L.E.; Pearce, W.J.
Maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared to adult ovine carotid arteries
Am. J. Physiol. Heart Circ. Physiol.
295
H2289-H2298
2008
Ovis aries (O02827)
Nakamura, A.; Xie, C.; Zhang, Y.; Gao, Y.; Wang, H.H.; Ye, L.H.; Kishi, H.; Okagaki, T.; Yoshiyama, S.; Hayakawa, K.; Ishikawa, R.; Kohama, K.
Role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi
Biochem. Biophys. Res. Commun.
369
135-143
2008
Bos taurus, Gallus gallus
Zhou, X.; Liu, Y.; You, J.; Zhang, H.; Zhang, X.; Ye, L.
Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2
Cancer Lett.
270
312-327
2008
Homo sapiens (Q15746)
Chan, J.Y.; Takeda, M.; Briggs, L.E.; Graham, M.L.; Lu, J.T.; Horikoshi, N.; Weinberg, E.O.; Aoki, H.; Sato, N.; Chien, K.R.; Kasahara, H.
Identification of cardiac-specific myosin light chain kinase
Circ. Res.
102
571-580
2008
Mus musculus (Q6PDN3)
Christie, J.D.; Ma, S.F.; Aplenc, R.; Li, M.; Lanken, P.N.; Shah, C.V.; Fuchs, B.; Albelda, S.M.; Flores, C.; Garcia, J.G.
Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma
Crit. Care Med.
36
2794-2800
2008
Homo sapiens
He, W.Q.; Peng, Y.J.; Zhang, W.C.; Lv, N.; Tang, J.; Chen, C.; Zhang, C.H.; Gao, S.; Chen, H.Q.; Zhi, G.; Feil, R.; Kamm, K.E.; Stull, J.T.; Gao, X.; Zhu, M.S.
Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice
Gastroenterology
135
610-620
2008
Mus musculus
Horman, S.; Morel, N.; Vertommen, D.; Hussain, N.; Neumann, D.; Beauloye, C.; El Najjar, N.; Forcet, C.; Viollet, B.; Walsh, M.P.; Hue, L.; Rider, M.H.
AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase
J. Biol. Chem.
283
18505-18512
2008
Mus musculus, Gallus gallus (P11799), Gallus gallus, Rattus norvegicus (P20689)
Borisov, A.B.; Raeker, M.O.; Russell, M.W.
Developmental expression and differential cellular localization of obscurin and obscurin-associated kinase in cardiac muscle cells
J. Cell. Biochem.
103
1621-1635
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Chilcoat, C.D.; Sharief, Y.; Jones, S.L.
Tonic protein kinase A activity maintains inactive beta2 integrins in unstimulated neutrophils by reducing myosin light-chain phosphorylation: role of myosin light-chain kinase and Rho kinase
J. Leukoc. Biol.
83
964-971
2008
Homo sapiens
Zhu, H.Q.; Cheng, X.W.; Xiao, L.L.; Jiang, Z.K.; Zhou, Q.; Gui, S.Y.; Wei, W.; Wang, Y.
Melatonin prevents oxidized low-density lipoprotein-induced increase of myosin light chain kinase activation and expression in HUVEC through ERK/MAPK signal transduction
J. Pineal Res.
45
328-334
2008
Homo sapiens
Fajmut, A.; Brumen, M.
MLC-kinase/phosphatase control of Ca2+ signal transduction in airway smooth muscles
J. Theor. Biol.
252
474-481
2008
Rattus norvegicus
Feighery, L.M.; Cochrane, S.W.; Quinn, T.; Baird, A.W.; OToole, D.; Owens, S.E.; ODonoghue, D.; Mrsny, R.J.; Brayden, D.J.
Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro
Pharm. Res.
25
1377-1386
2008
Homo sapiens, Mus musculus, Rattus norvegicus, Mus musculus C57BL/6
Moitra, J.; Evenoski, C.; Sammani, S.; Wadgaonkar, R.; Turner, J.R.; Ma, S.F.; Garcia, J.G.
A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age
Transl. Res.
151
141-153
2008
Homo sapiens
Han, Y.J.; Hu, W.Y.; Piano, M.; de Lanerolle, P.
Regulation of myosin light chain kinase expression by angiotensin II in hypertension
Am. J. Hypertens.
21
860-865
2008
Rattus norvegicus
Leguillette, R.; Laviolette, M.; Bergeron, C.; Zitouni, N.; Kogut, P.; Solway, J.; Kachmar, L.; Hamid, Q.; Lauzon, A.M.
Myosin, transgelin, and myosin light chain kinase: expression and function in asthma
Am. J. Respir. Crit. Care Med.
179
194-204
2009
Homo sapiens
Takashima, S.
Phosphorylation of myosin regulatory light chain by myosin light chain kinase, and muscle contraction
Circ. J.
73
208-213
2009
Rattus norvegicus
Xie, C.; Zhang, Y.; Wang, H.H.; Matsumoto, A.; Nakamura, A.; Ishikawa, R.; Yoshiyama, S.; Hayakawa, K.; Kohama, K.; Gao, Y.
Calcium regulation of non-kinase and kinase activities of recombinant myosin light-chain kinase and its mutants
IUBMB Life
61
1092-1098
2009
Gallus gallus, Bos taurus (Q28824)
Suzuki, T.; Nishimukai, M.; Takechi, M.; Taguchi, H.; Hamada, S.; Yokota, A.; Ito, S.; Hara, H.; Matsui, H.
The nondigestible disaccharide epilactose increases paracellular Ca absorption via Rho-associated kinase- and myosin light chain kinase-dependent mechanisms in rat small intestines
J. Agric. Food Chem.
58
1927-1932
2010
Rattus norvegicus
Zhang, W.C.; Peng, Y.J.; Zhang, G.S.; He, W.Q.; Qiao, Y.N.; Dong, Y.Y.; Gao, Y.Q.; Chen, C.; Zhang, C.H.; Li, W.; Shen, H.H.; Ning, W.; Kamm, K.E.; Stull, J.T.; Gao, X.; Zhu, M.S.
Myosin light chain kinase is necessary for tonic airway smooth muscle contraction
J. Biol. Chem.
285
5522-5531
2010
Mus musculus
Khuon, S.; Liang, L.; Dettman, R.W.; Sporn, P.H.; Wysolmerski, R.B.; Chew, T.L.
Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: a three-dimensional FRET study
J. Cell Sci.
123
431-440
2010
Bos taurus
Ye, D.; Ma, T.Y.
Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activity
J. Cell. Mol. Med.
12
1331-1346
2008
Homo sapiens
Miyauchi, E.; Morita, H.; Tanabe, S.
Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo
J. Dairy Sci.
92
2400-2408
2009
Homo sapiens, Mus musculus
Luh, C.; Kuhlmann, C.R.; Ackermann, B.; Timaru-Kast, R.; Luhmann, H.J.; Behl, C.; Werner, C.; Engelhard, K.; Thal, S.C.
Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury
J. Neurochem.
112
1015-1025
2009
Mus musculus
Raina, H.; Zacharia, J.; Li, M.; Wier, W.G.
Activation by Ca2+/calmodulin of an exogenous myosin light chain kinase in mouse arteries
J. Physiol.
587
2599-2612
2009
Mus musculus
Leveille, N.; Fournier, A.; Labrie, C.
Androgens down-regulate myosin light chain kinase in human prostate cancer cells
J. Steroid Biochem. Mol. Biol.
114
174-179
2009
Homo sapiens
Costantini, T.W.; Loomis, W.H.; Putnam, J.G.; Kroll, L.; Eliceiri, B.P.; Baird, A.; Bansal, V.; Coimbra, R.
Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase
J. Trauma
66
17-24
2009
Mus musculus
Obara, K.; Mitate, A.; Nozawa, K.; Watanabe, M.; Ito, Y.; Nakayama, K.
Interactive role of protein phosphatase 2A and protein kinase Calpha in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery
J. Vasc. Res.
47
115-127
2010
Canis lupus familiaris
Brown, M.; Adyshev, D.; Bindokas, V.; Moitra, J.; Garcia, J.G.; Dudek, S.M.
Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium
Microvasc. Res.
80
75-88
2010
Homo sapiens
Shin, D.H.; Chun, Y.S.; Lee, K.H.; Shin, H.W.; Park, J.W.
Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase
PLoS ONE
4
e7451
2009
Homo sapiens
Jin, Y.; Blikslager, A.T.
Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury
Am. J. Physiol. Cell Physiol.
311
C996-C1004
2016
Sus scrofa, Sus scrofa Yorkshire crossbred
Vilitkevich, E.L.; Khapchaev, A.Y.; Kudryashov, D.S.; Nikashin, A.V.; Schavocky, J.P.; Lukas, T.J.; Watterson, D.M.; Shirinsky, V.P.
Phosphorylation regulates interaction of 210-kDa myosin light chain kinase N-terminal domain with actin cytoskeleton
Biochemistry (Moscow)
80
1288-1297
2015
Gallus gallus (P11799)
Hong, F.; Facemyer, K.C.; Carter, M.S.; Jackson, d.e.l..R.; Haldeman, B.D.; Ruana, N.; Sutherland, C.; Walsh, M.P.; Cremo, C.R.; Baker, J.E.
Kinetics of myosin light chain kinase activation of smooth muscle myosin in an in vitro model system
Biochemistry
52
8489-8500
2013
Gallus gallus (P11799)
McGinnis, L.A.; Lee, H.J.; Robinson, D.N.; Evans, J.P.
MAPK3/1 (ERK1/2) and myosin light chain kinase in mammalian eggs affect myosin-II function and regulate the metaphase II state in a calcium- and zinc-dependent manner
Biol. Reprod.
92
146
2015
Mus musculus (Q3UIZ8), Mus musculus CF-1 (Q3UIZ8)
Alcala, D.B.; Haldeman, B.D.; Brizendine, R.K.; Krenc, A.K.; Baker, J.E.; Rock, R.S.; Cremo, C.R.
Myosin light chain kinase steady-state kinetics: comparison of smooth muscle myosin II and nonmuscle myosin IIB as substrates
Cell Biochem. Funct.
34
469-474
2016
Gallus gallus (P11799)
Martinsen, A.; Dessy, C.; Morel, N.
Regulation of calcium channels in smooth muscle: new insights into the role of myosin light chain kinase
Channels
8
402-413
2014
Rattus norvegicus (D3ZFU9), Rattus norvegicus Wistar (D3ZFU9)
Chen, C.; Tao, T.; Wen, C.; He, W.Q.; Qiao, Y.N.; Gao, Y.Q.; Chen, X.; Wang, P.; Chen, C.P.; Zhao, W.; Chen, H.Q.; Ye, A.P.; Peng, Y.J.; Zhu, M.S.
Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism
J. Biol. Chem.
289
28478-28488
2014
Mus musculus (Q6PDN3)
Lou, S.S.; Diz-Munoz, A.; Weiner, O.D.; Fletcher, D.A.; Theriot, J.A.
Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase
J. Cell Biol.
209
275-288
2015
Danio rerio (F1QPV1), Danio rerio, Danio rerio TL (F1QPV1)
Hong, F.; Brizendine, R.K.; Carter, M.S.; Alcala, D.B.; Brown, A.E.; Chattin, A.M.; Haldeman, B.D.; Walsh, M.P.; Facemyer, K.C.; Baker, J.E.; Cremo, C.R.
Diffusion of myosin light chain kinase on actin: A mechanism to enhance myosin phosphorylation rates in smooth muscle
J. Gen. Physiol.
146
267-280
2015
Homo sapiens (Q15746)
Li, L.; Wu, X.; Yue, H.Y.; Zhu, Y.C.; Xu, J.
Myosin light chain kinase facilitates endocytosis of synaptic vesicles at hippocampal boutons
J. Neurochem.
138
60-73
2016
Rattus norvegicus (P18666)
Shen, K.; Ramirez, B.; Mapes, B.; Shen, G.R.; Gokhale, V.; Brown, M.E.; Santarsiero, B.; Ishii, Y.; Dudek, S.M.; Wang, T.; Garcia, J.G.
Structure-function analysis of the non-muscle myosin light chain kinase (nmMLCK) isoform by NMR spectroscopy and molecular modeling: influence of MYLK variants
PLoS ONE
10
e0130515
2015
Homo sapiens
Taniguchi, M.; Okamoto, R.; Ito, M.; Goto, I.; Fujita, S.; Konishi, K.; Mizutani, H.; Dohi, K.; Hartshorne, D.J.; Itoh, T.
New isoform of cardiac myosin light chain kinase and the role of cardiac myosin phosphorylation in alpha1-adrenoceptor mediated inotropic response
PLoS ONE
10
e0141130
2015
Mus musculus (Q3UIZ8), Mus musculus, Mus musculus C57BL/6N/C57BL/6J (Q3UIZ8)
Watari, A.; Sakamoto, Y.; Hisaie, K.; Iwamoto, K.; Fueta, M.; Yagi, K.; Kondoh, M.
Rebeccamycin attenuates TNF-alpha-induced intestinal epithelial barrier dysfunction by inhibiting myosin light chain kinase production
Cell. Physiol. Biochem.
41
1924-1934
2017
Homo sapiens
Burbank, M.G.; Burban, A.; Sharanek, A.; Weaver, R.J.; Guguen-Guillouzo, C.; Guillouzo, A.
Early alterations of bile canaliculi dynamics and the Rho kinase/myosin light chain kinase pathway are characteristics of drug-induced intrahepatic cholestasis
Drug Metab. Dispos.
44
1780-1793
2016
Homo sapiens
Pai, Y.C.; Weng, L.T.; Wei, S.C.; Wu, L.L.; Shih, D.Q.; Targan, S.R.; Turner, J.R.; Yu, L.C.
Gut microbial transcytosis induced by tumor necrosis factor-like 1A-dependent activation of a myosin light chain kinase splice variant contributes to inflammatory bowel disease
J. Crohns Colitis
2021
258-272
2020
Homo sapiens (Q15746), Homo sapiens (Q9H1R3), Homo sapiens
Kamikubo, K.; Tsukamoto, O.; Uyama-Saito, Y.; Oya, R.; Tsubota, T.; Fujino, N.; Asano, Y.; Kato, H.; Matsuoka, K.; Takashima, S.
Non-radioactive in vitro cardiac myosin light chain kinase assays
J. Vis. Exp.
160
e61168
2020
Homo sapiens
Wang, T.; Mathew, B.; Wu, X.; Shimizu, Y.; Rizzo, A.N.; Dudek, S.M.; Weichselbaum, R.R.; Jacobson, J.R.; Hecker, L.; Garcia, J.G.
Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury
Pulm. Circ.
6
234-239
2016
Mus musculus
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