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Literature summary for 2.7.11.18 extracted from

  • Li, L.; Wu, X.; Yue, H.Y.; Zhu, Y.C.; Xu, J.
    Myosin light chain kinase facilitates endocytosis of synaptic vesicles at hippocampal boutons (2016), J. Neurochem., 138, 60-73.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information knockdown of endogenous MLCK by two shRNA sequences: shMLCK1 is 5-GCTAGATTTGACTGCAAGATT-3' and shMLCK 2 is 5'-ACTGTCCTCTATGGCAATGAT-3' Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ML-7 chemical inhibition of myosin light chain kinase (MLCK) slows down endocytosis Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
synaptic vesicle
-
Rattus norvegicus 8021
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, activates Rattus norvegicus
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [myosin light chain] Rattus norvegicus myyosin II ADP + [myosin light chain] phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P18666
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus hippocampal boutons Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [myosin light chain] myyosin II Rattus norvegicus ADP + [myosin light chain] phosphate
-
?
ATP + [myosin light chain] myosin II Rattus norvegicus ADP + [myosin light chain] phosphate
-
?

Synonyms

Synonyms Comment Organism
MLCK
-
Rattus norvegicus
Myl12b
-
Rattus norvegicus
myosin light chain kinase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22 24 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction induced endocytosis is slowed by acute inhibition of MLCK and by downregulation of MLCK via RNA interference while the total amount of vesicle exocytosis and somatic Ca2+channel current does not change with MLCK down-regulation. Downregulation of MLCK prevents depolarization-induced phosphorylation of myosin light chain, an effect shared by blockers of Ca2+ channels and calmodulin. Downregulation of MLCK does not decrease the amount of exocytosis Rattus norvegicus
physiological function myosin light chain kinase (MLCK) facilitates endocytosis of synaptic vesicles at hippocampal boutons through activity-dependent phosphorylation of myosin downstream of Ca2+/calmodulin. MLCK is an important activity-dependent regulator of vesicle recycling in hippocampal neurons, which are critical for learning and memory. MLCK positively regulates vesicle endocytosis at hippocampal boutons. MLCK regulates endocytosis by functioning between Ca2+/calmodulin and myosin Rattus norvegicus