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Literature summary for 2.7.11.18 extracted from
- Developmental expression and differential cellular localization of obscurin and obscurin-associated kinase in cardiac muscle cells (2008), J. Cell. Biochem., 103, 1621-1635.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activation of the RhoA pathway can inhibit myosin phosphatase activity, thereby enhancing the effects of the kinase-mediated phosphorylation of myosin light chain | Mus musculus | |
| additional information | activation of the RhoA pathway can inhibit myosin phosphatase activity, thereby enhancing the effects of the kinase-mediated phosphorylation of myosin light chain | Homo sapiens | |
| additional information | activation of the RhoA pathway can inhibit myosin phosphatase activity, thereby enhancing the effects of the kinase-mediated phosphorylation of myosin light chain | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| obscurin-associated kinase, DNA and amino acid sequence determination, sequence and expression analysis and comparison, both the mouse and human obscurinassociated kinase-like transcripts also share a conserved putative translation initiation site, overview. Expression in Escherichia coli strain BL21(DE3) | Homo sapiens |
| sequence and expression analysis and comparison, both the mouse and human obscurinassociated kinase-like transcripts also share a conserved putative translation initiation site, overview | Mus musculus |
| sequence and expression analysis and comparison, overview | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | PAK phosphorylation of MLCK by p21-activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Homo sapiens | |
| additional information | PAK phosphorylation of MLCK by p21-activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Mus musculus | |
| additional information | PAK phosphorylation of MLCK by p21-activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | exclusively | Mus musculus | 5737 | - |
| cytoplasm | exclusively | Homo sapiens | 5737 | - |
| cytoplasm | exclusively | Rattus norvegicus | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Mus musculus |  |
| Ca2+ | - |
Homo sapiens | |
| Ca2+ | - |
Rattus norvegicus | |
| Mg2+ | - |
Mus musculus | |
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin light chain | Mus musculus | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | Homo sapiens | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | Rattus norvegicus | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | ADP + myosin light chain phosphate | - |
? | |
| ATP + obscurin | Mus musculus | - |
ADP + obscurin phosphate | - |
? | |
| ATP + obscurin | Homo sapiens | - |
ADP + obscurin phosphate | - |
? | |
| ATP + obscurin | Rattus norvegicus | - |
ADP + obscurin phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | PAK phosphorylation of MLCK by p21- activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Mus musculus |
| phosphoprotein | PAK phosphorylation of MLCK by p21- activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Homo sapiens |
| phosphoprotein | PAK phosphorylation of MLCK by p21- activated kinase, a kinase activated by the Rho family of GTPases, can inhibit MLCK activity | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cardiac myocyte | primary cell culture | Mus musculus | - |
| cardiac myocyte | primary cell culture | Homo sapiens | - |
| cardiac myocyte | primary cell culture | Rattus norvegicus | - |
| heart | ventricle | Mus musculus | - |
| heart | ventricle | Homo sapiens | - |
| heart | ventricle | Rattus norvegicus | - |
| additional information | developmental pattern of obscurin and obscurin-associated kinase expression, overview | Mus musculus | - |
| additional information | developmental pattern of obscurin and obscurin-associated kinase expression, overview | Homo sapiens | - |
| additional information | developmental pattern of obscurin and obscurin-associated kinase expression, overview | Rattus norvegicus | - |
| muscle | expression of obscurin-MLCK-like kinase is restricted to muscles in the myonucleus | Mus musculus | - |
| muscle | expression of obscurin-MLCK-like kinase is restricted to muscles in the myonucleus | Homo sapiens | - |
| muscle | expression of obscurin-MLCK-like kinase is restricted to muscles in the myonucleus | Rattus norvegicus | - |
| myocardium | expression analysis, overview | Mus musculus | - |
| myocardium | expression analysis, overview | Homo sapiens | - |
| myocardium | expression analysis, overview | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin light chain | - |
Mus musculus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | - |
Homo sapiens | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | - |
Rattus norvegicus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | Mus musculus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | Homo sapiens | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | the MLCK family plays an essential role in regulation of actin/myosin organization, sarcomere assembly and cytoskeletal dynamics | Rattus norvegicus | ADP + myosin light chain phosphate | - |
? | |
| ATP + obscurin | - |
Mus musculus | ADP + obscurin phosphate | - |
? | |
| ATP + obscurin | - |
Homo sapiens | ADP + obscurin phosphate | - |
? | |
| ATP + obscurin | - |
Rattus norvegicus | ADP + obscurin phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MLCK | - |
Mus musculus |
| MLCK | - |
Homo sapiens |
| MLCK | - |
Rattus norvegicus |
| myosin light chain kinase | - |
Mus musculus |
| myosin light chain kinase | - |
Homo sapiens |
| myosin light chain kinase | - |
Rattus norvegicus |
| obscurin-associated kinase | - |
Mus musculus |
| obscurin-associated kinase | - |
Homo sapiens |
| obscurin-associated kinase | - |
Rattus norvegicus |
| obscurin-MLCK-like kinase | - |
Mus musculus |
| obscurin-MLCK-like kinase | - |
Homo sapiens |
| obscurin-MLCK-like kinase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
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