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Literature summary for 2.7.11.18 extracted from

  • Horman, S.; Morel, N.; Vertommen, D.; Hussain, N.; Neumann, D.; Beauloye, C.; El Najjar, N.; Forcet, C.; Viollet, B.; Walsh, M.P.; Hue, L.; Rider, M.H.
    AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase (2008), J. Biol. Chem., 283, 18505-18512.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on Mus musculus
Calmodulin dependent on Gallus gallus
Calmodulin dependent on Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information construction of 1-AMPK knock-out mice Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Mus musculus
Ca2+ dependent on Gallus gallus
Ca2+ dependent on Rattus norvegicus
Mg2+
-
Mus musculus
Mg2+
-
Gallus gallus
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin light chain Mus musculus activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, in aortic rings from mice in which alpha1, the major catalytic subunit isoform in arterial smooth muscle, is deleted, KCl- or phenylephrine-induced contraction is increased, overview ADP + phosphorylated myosin light chain
-
?
ATP + myosin light chain Gallus gallus activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK ADP + myosin light chain phosphate
-
?
ATP + myosin light chain Rattus norvegicus activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK ADP + myosin light chain phosphate
-
?
additional information Mus musculus MLCK is a substrate of AMP-activated protein kinase, AMPK ?
-
?
additional information Gallus gallus MLCK is a substrate of AMP-activated protein kinase, AMPK ?
-
?
additional information Rattus norvegicus MLCK is a substrate of AMP-activated protein kinase, AMPK ?
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus P11799
-
-
Mus musculus
-
-
-
Rattus norvegicus P20689
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Mus musculus
-
aorta
-
Rattus norvegicus
-
smooth muscle
-
Mus musculus
-
smooth muscle
-
Gallus gallus
-
smooth muscle
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin light chain
-
Mus musculus ADP + phosphorylated myosin light chain
-
?
ATP + myosin light chain activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, in aortic rings from mice in which alpha1, the major catalytic subunit isoform in arterial smooth muscle, is deleted, KCl- or phenylephrine-induced contraction is increased, overview Mus musculus ADP + phosphorylated myosin light chain
-
?
ATP + myosin light chain
-
Gallus gallus ADP + myosin light chain phosphate
-
?
ATP + myosin light chain
-
Rattus norvegicus ADP + myosin light chain phosphate
-
?
ATP + myosin light chain activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK Gallus gallus ADP + myosin light chain phosphate
-
?
ATP + myosin light chain activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK Rattus norvegicus ADP + myosin light chain phosphate
-
?
additional information MLCK is a substrate of AMP-activated protein kinase, AMPK Mus musculus ?
-
?
additional information MLCK is a substrate of AMP-activated protein kinase, AMPK Gallus gallus ?
-
?
additional information MLCK is a substrate of AMP-activated protein kinase, AMPK Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
MLCK
-
Mus musculus
MLCK
-
Gallus gallus
MLCK
-
Rattus norvegicus
myosin light chain kinase
-
Mus musculus
myosin light chain kinase
-
Gallus gallus
myosin light chain kinase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mus musculus
30
-
assay at Gallus gallus
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Mus musculus
7
-
assay at Gallus gallus
7
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus
ATP
-
Gallus gallus
ATP
-
Rattus norvegicus