Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on | Mus musculus | |
Calmodulin | dependent on | Gallus gallus | |
Calmodulin | dependent on | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of 1-AMPK knock-out mice | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Mus musculus | |
Ca2+ | dependent on | Gallus gallus | |
Ca2+ | dependent on | Rattus norvegicus | |
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Gallus gallus | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin light chain | Mus musculus | activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, in aortic rings from mice in which alpha1, the major catalytic subunit isoform in arterial smooth muscle, is deleted, KCl- or phenylephrine-induced contraction is increased, overview | ADP + phosphorylated myosin light chain | - |
? | |
ATP + myosin light chain | Gallus gallus | activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | Rattus norvegicus | activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK | ADP + myosin light chain phosphate | - |
? | |
additional information | Mus musculus | MLCK is a substrate of AMP-activated protein kinase, AMPK | ? | - |
? | |
additional information | Gallus gallus | MLCK is a substrate of AMP-activated protein kinase, AMPK | ? | - |
? | |
additional information | Rattus norvegicus | MLCK is a substrate of AMP-activated protein kinase, AMPK | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | P11799 | - |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | P20689 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Mus musculus | - |
aorta | - |
Rattus norvegicus | - |
smooth muscle | - |
Mus musculus | - |
smooth muscle | - |
Gallus gallus | - |
smooth muscle | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin light chain | - |
Mus musculus | ADP + phosphorylated myosin light chain | - |
? | |
ATP + myosin light chain | activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, in aortic rings from mice in which alpha1, the major catalytic subunit isoform in arterial smooth muscle, is deleted, KCl- or phenylephrine-induced contraction is increased, overview | Mus musculus | ADP + phosphorylated myosin light chain | - |
? | |
ATP + myosin light chain | - |
Gallus gallus | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | - |
Rattus norvegicus | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK | Gallus gallus | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | activated MLCK then phosphorylates the regulatory myosin light chains, triggering cross-bridge cycling and contraction, myosin light chain phosphorylation is increased under these conditions, suggesting that contraction would be potentiated by ablation of AMPK | Rattus norvegicus | ADP + myosin light chain phosphate | - |
? | |
additional information | MLCK is a substrate of AMP-activated protein kinase, AMPK | Mus musculus | ? | - |
? | |
additional information | MLCK is a substrate of AMP-activated protein kinase, AMPK | Gallus gallus | ? | - |
? | |
additional information | MLCK is a substrate of AMP-activated protein kinase, AMPK | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MLCK | - |
Mus musculus |
MLCK | - |
Gallus gallus |
MLCK | - |
Rattus norvegicus |
myosin light chain kinase | - |
Mus musculus |
myosin light chain kinase | - |
Gallus gallus |
myosin light chain kinase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
30 | - |
assay at | Gallus gallus |
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Mus musculus |
7 | - |
assay at | Gallus gallus |
7 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Gallus gallus | |
ATP | - |
Rattus norvegicus |