Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ML-7 | ie. 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazapine hydrochloride, a specific inhibitor of MLCK, ML-7 is able to depress the cell proliferation and migration in vivo using two parallel breast cancer cell lines. ML-7 not only blocks MLCK but also downregulates activated ERK1/2 with downstream effectors of beta-catenin-survivin-cyclin D1-c-Myc, overview | Homo sapiens | |
additional information | the inhibitor of ERK1/2, PD98059, downregulates the levels of MLCK and phosphorylated myosin light chain | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin light chain | Homo sapiens | MLCK plays a crucial role in the cell migration and tumor metastasis | ADP + myosin light chain phosphate | - |
? | |
additional information | Homo sapiens | myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q15746 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myosin light chain | - |
Homo sapiens | ADP + myosin light chain phosphate | - |
? | |
ATP + myosin light chain | MLCK plays a crucial role in the cell migration and tumor metastasis | Homo sapiens | ADP + myosin light chain phosphate | - |
? | |
additional information | myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MLCK | - |
Homo sapiens |
myosin light-chain kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |