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Literature summary for 2.7.11.18 extracted from

  • Lamprecht, R.; Margulies, D.S.; Farb, C.R.; Hou, M.; Johnson, L.R.; LeDoux, J.E.
    Myosin light chain kinase regulates synaptic plasticity and fear learning in the lateral amygdala (2006), Neuroscience, 139, 821-829.
    View publication on PubMed
Search for more literature for 2.7.11.18

Inhibitors

Inhibitors Comment Organism Structure
ML-7 a specific inhibitor, in vivo the inhibitor enhances the short-term and long-term memory, when applied before fear conditioning, but not immediately afterwards, the inhibitor has no effet on memory retrieval and behaviour when the training stimuli are presented in a non-associative manner Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
synapse of lateral amygdala Rattus norvegicus 45202
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme negatively regulates synaptic plasticity and fear learning in the lateral nucleus of the amygdala, the enzyme is involved in memory aquisitoion, rather than in posttraining consolidation of memory, the enzyme may help to prevent aquisition of irrelevant fears, thus enzyme deficiency or defects can lead to pathological fear learning, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala lateral Rattus norvegicus
-
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme negatively regulates synaptic plasticity and fear learning in the lateral nucleus of the amygdala, the enzyme is involved in memory aquisitoion, rather than in posttraining consolidation of memory, the enzyme may help to prevent aquisition of irrelevant fears, thus enzyme deficiency or defects can lead to pathological fear learning, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
myosin light chain kinase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus