Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + light chain myosin II | Homo sapiens | cytokine-induced epithelial barrier dysfunction can be mediated by increased MLCK expression and subsequent myosin II regulatory light chain phosphorylation, the enzyme is involved in the inflammatory bowel disease | ADP + phosphorylated light chain myosin II | - |
? | |
additional information | Homo sapiens | increased MLCK activity accompanies increases in MLC expression, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | epithelium | Homo sapiens | - |
epithelium | - |
Homo sapiens | - |
ileum | ileal epithelial MLCK expression is mildly upregulated in inactive inflammatory bowel disease, and highly upregulated in active IBD | Homo sapiens | - |
intestine | epithelium, expression of MLVK is upregulated by inflammatory bowel disease | Homo sapiens | - |
additional information | tissue dependent MLCK expression analysis of 26 inflammatory bowel disease patients | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + light chain myosin II | cytokine-induced epithelial barrier dysfunction can be mediated by increased MLCK expression and subsequent myosin II regulatory light chain phosphorylation, the enzyme is involved in the inflammatory bowel disease | Homo sapiens | ADP + phosphorylated light chain myosin II | - |
? | |
ATP + light chain myosin II | regulatory myosin light chain | Homo sapiens | ADP + phosphorylated light chain myosin II | - |
? | |
additional information | increased MLCK activity accompanies increases in MLC expression, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MLCK | - |
Homo sapiens |
myosin light chain kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |