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Literature summary for 2.7.11.18 extracted from

  • Shimizu, S.; Yoshida, T.; Wakamori, M.; Ishii, M.; Okada, T.; Takahashi, M.; Seto, M.; Sakurada, K.; Kiuchi, Y.; Mori, Y.
    Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells (2006), J. Physiol., 570, 219-235.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.18

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin activates, dependent on Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, expressionin HEK-293 cells, co-expression with TRPC5 from Drosophila melanogaster Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information expression of a dominant-negative mutant of MLCK inhibits the TRPC5 channel activity, revealing an essential role of MLCK in maintaining TRPC5 channel activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ML-9 impairs the plasma membrane localization of TRPC5 channels; impairs the plasma membrane localization of TRPC5 channels Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates, dependent on Homo sapiens
Mg2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15746 smooth muscle isozyme MYLK
-
Homo sapiens Q9H1R3 skeletal/cardiac muscle isozyme MYLK2
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac muscle
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-
smooth muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + TRPC5 channel Ca2+/calmodulin-dependent myosin light chain kinase is essential for activation of plasma membrane TRPC5 channels, responsible for Ca2+ influx, from Drosophila melanogaster expressed in HEK-293 cells, phosphorylation sites are Ser698, Ser775, and Thr700, mutational analysis Homo sapiens ADP + phosphorylated TRPC5 channel
-
 ?
additional information MLCK in the plasma membrane distribution of TRPC5 channels, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Ca2+-calmodulin-dependent myosin light chain kinase
-
 Homo sapiens
MLCK
-
 Homo sapiens
More cf. EC 2.7.11.17 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens