Literature summary for 2.7.11.18 extracted from

Grimm, M.; Haas, P.; Willipinski-Stapelfeldt, B.; Zimmermann, W.H.; Rau, T.; Pantel, K.; Weyand, M.; Eschenhagen, T.
Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium (2005), Cardiovasc. Res., 65, 211-220.

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Activating Compound

Activating Compound	Comment	Organism	Structure
isoprenaline	80% activation at up to 0.01 mM	Homo sapiens
phenylephrine	80% activation at up to 0.1 mM	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
ML-7	strong specific inhibition	Homo sapiens
Wortmannin	complete inhibition at 0.01 mM	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [myosin light chain 2a]	Homo sapiens	MLC phosphorylation plays a regulatory role in inotropic response to alpha1-adrenergic stimulation in the heart, enzyme inhibition causes heart failure in ventricular trabeculae	ADP + [myosin light chain 2a] phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
atrium	-	Homo sapiens	-
heart	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [myosin light chain 2a]	-	Homo sapiens	ADP + [myosin light chain 2a] phosphate	-	?
ATP + [myosin light chain 2a]	MLC phosphorylation plays a regulatory role in inotropic response to alpha1-adrenergic stimulation in the heart, enzyme inhibition causes heart failure in ventricular trabeculae	Homo sapiens	ADP + [myosin light chain 2a] phosphate	-	?

Synonyms

Synonyms	Comment	Organism
MLC kinase	-	Homo sapiens
MLCK	-	Homo sapiens
myosin light chain kinase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)