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Literature summary for 2.7.11.18 extracted from

  • Chan, J.Y.; Takeda, M.; Briggs, L.E.; Graham, M.L.; Lu, J.T.; Horikoshi, N.; Weinberg, E.O.; Aoki, H.; Sato, N.; Chien, K.R.; Kasahara, H.
    Identification of cardiac-specific myosin light chain kinase (2008), Circ. Res., 102, 571-580.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.18

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, expression analysis in cardiac smooth muscle, overview, expression of HA-tagged MLCK Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0043
-
 myosin light chain cardiac MLCK Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm subcellular localization study Mus musculus 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin light chain 2 Mus musculus MLCK is involved in sarcomere organization, cardiac MLCK promotes sarcomere organization and increases cardiomyocyte contractility, overview ADP + myosin light chain 2 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q6PDN3
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the cardiac-specific isozyme probably performs also autophosphorylation Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Mus musculus
-
heart cardiac-specific myosin light chain kinase Mus musculus
-
smooth muscle cardiac Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin light chain 2
-
 Mus musculus ADP + myosin light chain 2 phosphate
-
 ?
ATP + myosin light chain 2 MLCK is involved in sarcomere organization, cardiac MLCK promotes sarcomere organization and increases cardiomyocyte contractility, overview Mus musculus ADP + myosin light chain 2 phosphate
-
 ?
additional information the cardiac-specific isozyme probably performs also autophosphorylation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
cardiac-specific myosin light chain kinase
-
 Mus musculus
MLCK
-
 Mus musculus
myosin light chain kinase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus