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Literature summary for 2.7.11.18 extracted from

  • Song, K.H.; Lee, J.; Jung, H.R.; Park, H.; Doh, J.
    Turning behaviors of T cells climbing up ramp-like structures are regulated by myosin light chain kinase activity and lamellipodia formation (2017), Sci. Rep., 7, 11533 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [myosin light chain] Mus musculus
-
 ADP + [myosin light chain] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [myosin light chain]
-
 Mus musculus ADP + [myosin light chain] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
MLCK
-
 Mus musculus
myosin light chain kinase
-
 Mus musculus

General Information

General Information Comment Organism
physiological function lamellipodia contractility regulated by the enzyme is responsible for the intriguing turning behavior of T cells climbing sharp-edged ramp-like structures. The enzyme activity is responsible for the reduction of velocity and turning of T cells encountering ramp-like structures Mus musculus