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Literature summary for 2.7.11.18 extracted from

  • Costantini, T.W.; Loomis, W.H.; Putnam, J.G.; Kroll, L.; Eliceiri, B.P.; Baird, A.; Bansal, V.; Coimbra, R.
    Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase (2009), J. Trauma, 66, 17-24.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.18

Activating Compound

Activating Compound Comment Organism Structure
additional information treatment with pentoxifylline attenuates activation of MLCK likely through its ability to decrease local tumor necrosis factor-alpha synthesis and nucleat factor kappaB activation after burn Mus musculus
tumor necrosis factor-alpha
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
small intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin light chain
-
 Mus musculus ADP + myosin light chain phosphate
-
 ?

Synonyms

Synonyms Comment Organism
MLCK
-
 Mus musculus
myosin light chain kinase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus severe burn injury increases intestinal MLCK protein levels 3.6fold after 2h in animals resuscitated with normal saline up