3.1.4.3: phospholipase C
This is an abbreviated version!
For detailed information about phospholipase C, go to the full flat file.
Word Map on EC 3.1.4.3
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3.1.4.3
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inositol
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agonist
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phosphatidylinositol
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pkc
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phospholipid
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diacylglycerol
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phosphoinositide
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cyclase
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pertussis
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camp
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phorbol
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g-proteins
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platelet
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arachidonic
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1,4,5-trisphosphate
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4,5-bisphosphate
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receptor-mediated
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vibrio
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thapsigargin
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trisphosphate
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adenylate
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protein-coupled
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blocker
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adenylyl
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phospholipases
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muscarinic
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phosphatidic
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cereus
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carbachol
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perfringens
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pip2
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fura-2
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neomycin
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ca2+-free
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phosphatidylinositol-specific
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metabotropic
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13-acetate
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thromboxane
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nifedipine
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parahaemolyticus
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staurosporine
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bradykinin
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enterotoxin
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desensitization
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ryanodine
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prelabeled
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toxin-sensitive
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store-operated
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chelerythrine
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agonist-induced
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analysis
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drug development
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medicine
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food industry
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pharmacology
- 3.1.4.3
- inositol
- agonist
- phosphatidylinositol
- pkc
- phospholipid
- diacylglycerol
- phosphoinositide
- cyclase
- pertussis
- camp
-
phorbol
- g-proteins
- platelet
-
arachidonic
- 1,4,5-trisphosphate
- 4,5-bisphosphate
-
receptor-mediated
- vibrio
- thapsigargin
- trisphosphate
- adenylate
-
protein-coupled
-
blocker
-
adenylyl
- phospholipases
-
muscarinic
-
phosphatidic
- cereus
- carbachol
- perfringens
- pip2
-
fura-2
- neomycin
-
ca2+-free
-
phosphatidylinositol-specific
-
metabotropic
-
13-acetate
-
thromboxane
- nifedipine
- parahaemolyticus
- staurosporine
- bradykinin
- enterotoxin
-
desensitization
-
ryanodine
-
prelabeled
-
toxin-sensitive
-
store-operated
- chelerythrine
-
agonist-induced
- analysis
- drug development
- medicine
- food industry
- pharmacology
Reaction
Synonyms
alpha-toxin, Beta toxin, Beta-hemolysin, Beta-toxin, broad-range phospholipase C, Cbp, CegC1, cholinespecific glycerophosphodiester phosphodiesterase, Clostridium oedematiens beta- and gamma-toxins, Clostridium welchii alpha-toxin, cPC-PLC, CpPLC, Dot/Icm-injected effector, Gamma-toxin, haemolytic phospholipase C, Heat labile-hemolysin, heat-labile hemolysin, Hemolysin, hemolytic PLC, hNPP6, Lecithinase, lecithinase C, lipophosphodiesterase C, lipophosphodiesterase I, Lpg0012, mNPP6, More, mPC-PLC, MTP40 antigen, non-specific phospholipase C, nonhemolytic PLC, nonspecific phospholipase C, NPC, NPC1, NPC1a, NPC1b, NPC2, NPC2a, NPC2b, NPC3, NPC3a, NPC3b, NPC4, NPC5, NPC6, NPC6a, NPC6b, NPC6c, NPC6d, NPP6, nucleotide pyrophosphatase/phosphodiesterase, PC-PLC, phosphatidase C, Phosphatidylcholine cholinephosphohydrolase, phosphatidylcholine phospholipase C, phosphatidylcholine specific phospholipase C, phosphatidylcholine-hydrolysing phospholipase C, phosphatidylcholine-hydrolyzing phospholipase C, phosphatidylcholine-preferring PLC, phosphatidylcholine-specific phospholipase C, phospholipase C, phospholipase C beta 1, phospholipase C gamma 1, phospholipase C gamma 2, phospholipase C/sphingomyelinase, phospholipase C/sphingomyelinase HR2, PLC, PLC-Bt, PLC-H, PLC-N, PLC1, PLC2, PlcB, PLCBC, PLCbeta, plcC, PlcC protein, PlcC/CegC1, PLCG1, PLCG2, PLCgamma, PlcHR2, PlcHR2 toxin, PLCLM, protein kinase C, PtdCho-PLC, Rv3487c, SMase, SMc00171, sphingomyelinase, type C phospholipase
ECTree
3.1.4.3 phospholipase CAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.1.4.3 - phospholipase C
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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in vitro vasculogenesis model. Activities of both Ca2+-dependent and independent isoform PC-PLC and the level of reactive oxygen species are elevated during the endothelial differentiation of the blastodisc. Ca2+-independent PC-PLC undergoes an increase in 24 h, then decreases gradually with the cell differentiation, while Ca2+-dependent PC-PLC is almost not changed during the process
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a rat hepatoma cell line established from N-nitrosodiethyla-mine-induced Wistar rat hepatoma
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stably expressing human imidazoline receptor antisera-selected protein IRAS
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different cell lines of epithelial ovarian cancer cells (EOC) compared with nontumoral (normal or immortalized) counterparts (EONT)
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substantial intracellular amounts of isoform PC-PLC in all lymphoid subsets
additional information
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suppression of isoform PC-PLC inhibits apoptosis in young cells, but not in senescent cells, and depresses reactive oxygen species levels in both young and senescent cells
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monocyte-derived macrophage, enzyme is activated by HIV-1 R5 gp120 interaction with CCR5 and is required for NF-kB-mediated chemokine CCL2 production triggered by R5 gp120
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suppression of isoform PC-PLC in presence of basic fibroblast growth factor can induce neuronal differentiation accompanied by increase in viability of differentiated cells. The resting membrane potential of the differentiated cells gradually decreases, but the mitochondrial membrane potential rises with increasing inhibition time
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high level of enzyme expression on the outer membrane surface. Identification of two subsets of cells, CD56dimPC-PLCbright and CD56brightPC-PLClow/-, corresponding to distinct subsets with cytolytic and immunoregulatory function. Enzyme expression level on the membrane closely correlates with that of the CD16 receptor
higher in seedling hypocotyls and lower in seedling roots
additional information
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overlapping expression pattern of NPC genes in root, stem, leaf, flower, and silique
additional information
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no detection of enzyme expression on CD4+ and CD8+ T lymphocytes
additional information
no expression of NPP6 detectable in heart, stomach, placenta, intestine, and leukocyte
additional information
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no expression of NPP6 detectable in heart, stomach, placenta, intestine, and leukocyte
additional information
no expression of NPP6 detectable in Modulla oblongata and uterus
