3.1.4.3: phospholipase C
This is an abbreviated version!
For detailed information about phospholipase C, go to the full flat file.
Word Map on EC 3.1.4.3
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3.1.4.3
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inositol
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agonist
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phosphatidylinositol
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pkc
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phospholipid
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diacylglycerol
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phosphoinositide
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cyclase
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pertussis
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camp
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phorbol
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g-proteins
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platelet
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arachidonic
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1,4,5-trisphosphate
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4,5-bisphosphate
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receptor-mediated
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vibrio
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thapsigargin
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trisphosphate
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adenylate
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protein-coupled
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blocker
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adenylyl
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phospholipases
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muscarinic
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phosphatidic
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cereus
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carbachol
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perfringens
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pip2
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fura-2
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neomycin
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ca2+-free
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phosphatidylinositol-specific
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metabotropic
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13-acetate
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thromboxane
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nifedipine
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parahaemolyticus
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staurosporine
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bradykinin
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enterotoxin
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desensitization
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ryanodine
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prelabeled
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toxin-sensitive
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store-operated
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chelerythrine
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agonist-induced
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analysis
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drug development
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medicine
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food industry
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pharmacology
- 3.1.4.3
- inositol
- agonist
- phosphatidylinositol
- pkc
- phospholipid
- diacylglycerol
- phosphoinositide
- cyclase
- pertussis
- camp
-
phorbol
- g-proteins
- platelet
-
arachidonic
- 1,4,5-trisphosphate
- 4,5-bisphosphate
-
receptor-mediated
- vibrio
- thapsigargin
- trisphosphate
- adenylate
-
protein-coupled
-
blocker
-
adenylyl
- phospholipases
-
muscarinic
-
phosphatidic
- cereus
- carbachol
- perfringens
- pip2
-
fura-2
- neomycin
-
ca2+-free
-
phosphatidylinositol-specific
-
metabotropic
-
13-acetate
-
thromboxane
- nifedipine
- parahaemolyticus
- staurosporine
- bradykinin
- enterotoxin
-
desensitization
-
ryanodine
-
prelabeled
-
toxin-sensitive
-
store-operated
- chelerythrine
-
agonist-induced
- analysis
- drug development
- medicine
- food industry
- pharmacology
Reaction
Synonyms
alpha-toxin, Beta toxin, Beta-hemolysin, Beta-toxin, broad-range phospholipase C, Cbp, CegC1, cholinespecific glycerophosphodiester phosphodiesterase, Clostridium oedematiens beta- and gamma-toxins, Clostridium welchii alpha-toxin, cPC-PLC, CpPLC, Dot/Icm-injected effector, Gamma-toxin, haemolytic phospholipase C, Heat labile-hemolysin, heat-labile hemolysin, Hemolysin, hemolytic PLC, hNPP6, Lecithinase, lecithinase C, lipophosphodiesterase C, lipophosphodiesterase I, Lpg0012, mNPP6, More, mPC-PLC, MTP40 antigen, non-specific phospholipase C, nonhemolytic PLC, nonspecific phospholipase C, NPC, NPC1, NPC1a, NPC1b, NPC2, NPC2a, NPC2b, NPC3, NPC3a, NPC3b, NPC4, NPC5, NPC6, NPC6a, NPC6b, NPC6c, NPC6d, NPP6, nucleotide pyrophosphatase/phosphodiesterase, PC-PLC, phosphatidase C, Phosphatidylcholine cholinephosphohydrolase, phosphatidylcholine phospholipase C, phosphatidylcholine specific phospholipase C, phosphatidylcholine-hydrolysing phospholipase C, phosphatidylcholine-hydrolyzing phospholipase C, phosphatidylcholine-preferring PLC, phosphatidylcholine-specific phospholipase C, phospholipase C, phospholipase C beta 1, phospholipase C gamma 1, phospholipase C gamma 2, phospholipase C/sphingomyelinase, phospholipase C/sphingomyelinase HR2, PLC, PLC-Bt, PLC-H, PLC-N, PLC1, PLC2, PlcB, PLCBC, PLCbeta, plcC, PlcC protein, PlcC/CegC1, PLCG1, PLCG2, PLCgamma, PlcHR2, PlcHR2 toxin, PLCLM, protein kinase C, PtdCho-PLC, Rv3487c, SMase, SMc00171, sphingomyelinase, type C phospholipase
ECTree
3.1.4.3 phospholipase CAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 3.1.4.3 - phospholipase C
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
1-[6-[[(17beta)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione
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i.e. U-73122, a phospholipase C inhibitor
1-[hydroxy[2-(trimethylammonio)ethyl]amino]-1-oxododecan-2-aminium
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uncompetitive inhibition
1-[hydroxy[3-(trimethylammonio)propyl]amino]-1-oxododecan-2-aminium
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mixed type inhibition
2-[(benzyloxy)[2-[(tert-butoxycarbonyl)amino]dodecanoyl]amino]-N,N,N-trimethylethanaminium
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2-[(benzyloxy)[2-[(tert-butoxycarbonyl)amino]hexadecanoyl]amino]-N,N,N-trimethylethanaminium
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2-[(benzyloxy)[2-[(tert-butoxycarbonyl)amino]icosanoyl]amino]-N,N,N-trimethylethanaminium
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2-[(benzyloxy)[2-[(tert-butoxycarbonyl)amino]octanoyl]amino]-N,N,N-trimethylethanaminium
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3(S),4-dihexanoylbutyl-1-phosphonycholine
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non-hydrolyzable, competitive inhibitor of bacterial PLC, analog of the natural phospholipid substrate, binds with its phosphonyl group to the three Zn-ions in the active site of the enzyme
3-[(benzyloxy)[2-[(tert-butoxycarbonyl)amino]dodecanoyl]amino]-N,N,N-trimethylpropan-1-aminium
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mixed type inhibition
3-[(benzyloxy)[2-[(tert-butoxycarbonyl)amino]octanoyl]amino]-N,N,N-trimethylpropan-1-aminium
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48/80
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compound 48/80, oligomeric mixture of condensation products of N-methyl-p-methoxyphenethylamine and formaldehyde. Specific inhibition of phosphatidylinositol-specific phospholipase C, i.e. PI-PLC. Suppression of PI-PLC promotes apoptosis of vascular endothelial cells by inhibiting Akt phosphorylation, elevating p53 expression, and affecting cell cycle distribution
AlCl3
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at 1 mM, about 60% inhibition of soluble isoform, 50% inhibition of membrane-associated isoform, inhibition of root growth
EGTA
enzyme activity against 1-myristoyl-lysophosphatidylcholine, glycerophosphorylcholine, and p-nitrophenyl phosphorylcholine are readily inhibited by EGTA. Indicates that a divalent cation is essential for catalytic activity
tert-butyl (1-[(benzyloxy)[3-(dimethylamino)propyl]amino]-1-oxododecan-2-yl)carbamate
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noncompetitive inhibition
tert-butyl (1-[(benzyloxy)[3-(dimethylamino)propyl]amino]-1-oxooctan-2-yl)carbamate
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tricyclodecan-9-yl-potassium xanthate
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The recovery of both variables to their original levels in serum-restimulated (or lysophosphatidic acid-restimulated) EOC cells is strongly delayed, for at least 24 h, in the presence of the PC-PLC inhibitor tricyclodecan-9-yl-potassium xanthate (D609). The S-phase of serum-restimulated EONT cells is not sensitive to D609
Al3+
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Al3+-mediated plasma membrane rigidity decreases the enzyme activity
Ca2+
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inhibits phosphatidylethanolamine hydrolysis
Ca2+
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activity rapidly decreases at concentrations of 0.015-0.030 mM and above
Cu2+
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study of in vivo inhibitory capacity, time course, recovery after 7 days
D609
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i.e. tricyclodecan-9-yl potassium xanthate, inhibition of isoform PC-PLC. After application on blastodisc at 24 h, cell differentiation cannot progress and intracellular level of reactive oxygen species is elevated
D609
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specific inhibition of phosphatidylcholine-specific phospholipase C, i.e. PC-PLC. Suppression of PC-PLC promotes the phosphorylation of Akt protein
D609
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inhibitor of isoform PC-PLC, preincubation with D609 results in a dramatic decrease both in CD16 receptor and PC-PLC expression on the plasma membrane and reduction of CD16-mediated cytotoxicity
D609
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suppression of isoform PC-PLC by D609 inhibits apoptosis in young cells, but not in senescent cells, and depresses reactive oxygen species levels in both young and senescent cells
D609
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inhibition of isoform PC-PLC blocks the silica-stimulated induction of TNF-alpha and interleukin-1beta
D609
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inhibition of isoform PC-PLC activity coupled with induction of neuronal differentiation. Simultaneously, the level of reactive oxygen species, and the activity of NADPH oxidase increase significantly, without alteration of the levels of Mn-superoxide dismutase and Cu/ZN superoxide dismutase
EDTA
enzyme activity against 1-myristoyl-lysophosphatidylcholine, glycerophosphorylcholine, and p-nitrophenyl phosphorylcholine are readily inhibited by EDTA. Indicates that a divalent cation is essential for catalytic activity
Hg2+
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study of in vivo inhibitory capacity, time course, recovery after 7 days
Mg2+
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inhibits phosphatidylethanolamine hydrolysis
Mn2+
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inhibits phosphatidylethanolamine hydrolysis
o-phenanthroline
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inhibits the phospholipase C hydrolytic activity of the enzyme, but not its membrane fusion activity
tricyclodecan-9-yl-xanthogenate
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inhibition is associated with decrease of enzyme exposed on cell surface and accumulation of cytoplasmic enzyme in Golgi region; preincubation of NK cells with a PC-PLC inhibitor, tricyclodecan-9-yl-xanthogenate, strongly reduced NK-mediated cytotoxicity
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tricyclodecan-9-yl-xanthogenate
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i.e. D609, a specific inhibitor, significantly suppresses the (S)-3-methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide-induced current in type I nNOS neurons
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tricyclodecan-9-yl-xanthogenate
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i.e. D609, specific inhibitor, does not inhibit sphingomyelin synthase
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tricyclodecan-9-yl-xanthogenate
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i.e. D609, a specific inhibitor, prevents the development of acute hypoxic pulmonary hypertension in rats, and also inhibits pulmonary vasoconstriction induced with a generator of superoxide anions LY83583, but not the one induced with hydrogen peroxide
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tricyclodecan-9-ylxanthogenate
i.e. D609; i.e. D609; i.e. D609; i.e. D609; i.e. D609; i.e. D609
tricyclodecan-9-ylxanthogenate
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i.e. D609, a rather selective PC-PLC inhibitor
U-73122
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inhibition of enzyme in single myocytes by 0.005 mM completely blocks rises in Ca2+ concentration induced by both carbachol and ATP
U-73122
general PLC antagonist, abolishes all PLC activities of eggs, blocks fertilization-induced egg activation; PLC antagonist, abolishes all PLC activities of eggs ,blocks fertilization-induced egg activation
additional information
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PC-PLCBc inhibition is not due to the interaction of compounds with the phospholipase catalytic zinc atoms, but rather results from the inhibitor cationic group recognition by the PCPLCBc amino acids involved in choline lipid binding. Inhibitor design based on 2-aminohydroxamic acid PC-PLCBc inhibitors that block the enzyme by coordination of the zinc active site atoms present in PC-PLCBc, overview
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additional information
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excess diacylglycerol at pH 7.5 at approximately 12% inhibits the membrane fusion activity of the enzyme
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additional information
U-73343, has no effect on egg activation; U-73343, has no effect on egg activation
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additional information
U-73343, has no effect on egg activation; U-73343, has no effect on egg activation
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additional information
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no effect on activity by monosialic ganglioside GM3 and phospholipids
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additional information
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inhibition of enzyme leads to inhibition of IL-2 induced proliferation of cells
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additional information
the catalytic activity of NPP6 toward p-nitrophenyl phosphorylcholine is partially inhibited by the divalent cations. Attempts are unsuccessful to recover the activity of EDTA treated NPP6 by adding various divalent cations
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additional information
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the catalytic activity of NPP6 toward p-nitrophenyl phosphorylcholine is partially inhibited by the divalent cations. Attempts are unsuccessful to recover the activity of EDTA treated NPP6 by adding various divalent cations
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additional information
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no inhibition by tricyclodecan-9-ylxanthogenate, i.e. D609
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additional information
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the recombinant enzyme is resistant to 20 mM CHAPS or 20 mM Triton X-100
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additional information
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no inhibition of enzymatic activity by Ca2+, inhibits haemolytic activity of the enzyme
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additional information
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inhibition of phosphatidylcholine-specific phospholipase C prevents the inhibition of gap junctional intercellular communication by 1-methylanthracene
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