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Literature summary for 3.1.4.3 extracted from

  • Li, F.; Wu, N.; Su, R.B.; Zheng, J.Q.; Xu, B.; Lu, X.Q.; Cong, B.; Li, J.
    Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein (2006), J. Cell. Biochem., 98, 1615-1628.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
moxonidine incubation of CHO cells stably expressing human imidazoline receptor antisera-selected protein IRAS for 5 min can induce an upregulation of isoform PC-PLC activity and an increase in the accumulation of reaction product diacylglycerol Cricetulus griseus
rilmenidine incubation of CHO cells stably expressing human imidazoline receptor antisera-selected protein IRAS for 5 min can induce an upregulation of isoform PC-PLC activity and an increase in the accumulation of reaction product diacylglycerol Cricetulus griseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cricetulus griseus the signaling pathway of human imidazoline receptor antisera-selected protein IRAS in response to I1-imidazoline receptor agonists is coupled with the activation of isoform PC-PLC and its downstream signal transduction molecule ERK ?
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Organism

Organism UniProt Comment Textmining
Cricetulus griseus
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Source Tissue

Source Tissue Comment Organism Textmining
CHO cell stably expressing human imidazoline receptor antisera-selected protein IRAS Cricetulus griseus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the signaling pathway of human imidazoline receptor antisera-selected protein IRAS in response to I1-imidazoline receptor agonists is coupled with the activation of isoform PC-PLC and its downstream signal transduction molecule ERK Cricetulus griseus ?
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 ?