Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.1.4.3: phospholipase C

This is an abbreviated version!
For detailed information about phospholipase C, go to the full flat file.

Word Map on EC 3.1.4.3

Reaction

a phosphatidylcholine
+
H2O
=
1,2-diacyl-sn-glycerol
 +
phosphocholine

Synonyms

alpha-toxin, Beta toxin, Beta-hemolysin, Beta-toxin, broad-range phospholipase C, Cbp, CegC1, cholinespecific glycerophosphodiester phosphodiesterase, Clostridium oedematiens beta- and gamma-toxins, Clostridium welchii alpha-toxin, cPC-PLC, CpPLC, Dot/Icm-injected effector, Gamma-toxin, haemolytic phospholipase C, Heat labile-hemolysin, heat-labile hemolysin, Hemolysin, hemolytic PLC, hNPP6, Lecithinase, lecithinase C, lipophosphodiesterase C, lipophosphodiesterase I, Lpg0012, mNPP6, More, mPC-PLC, MTP40 antigen, non-specific phospholipase C, nonhemolytic PLC, nonspecific phospholipase C, NPC, NPC1, NPC1a, NPC1b, NPC2, NPC2a, NPC2b, NPC3, NPC3a, NPC3b, NPC4, NPC5, NPC6, NPC6a, NPC6b, NPC6c, NPC6d, NPP6, nucleotide pyrophosphatase/phosphodiesterase, PC-PLC, phosphatidase C, Phosphatidylcholine cholinephosphohydrolase, phosphatidylcholine phospholipase C, phosphatidylcholine specific phospholipase C, phosphatidylcholine-hydrolysing phospholipase C, phosphatidylcholine-hydrolyzing phospholipase C, phosphatidylcholine-preferring PLC, phosphatidylcholine-specific phospholipase C, phospholipase C, phospholipase C beta 1, phospholipase C gamma 1, phospholipase C gamma 2, phospholipase C/sphingomyelinase, phospholipase C/sphingomyelinase HR2, PLC, PLC-Bt, PLC-H, PLC-N, PLC1, PLC2, PlcB, PLCBC, PLCbeta, plcC, PlcC protein, PlcC/CegC1, PLCG1, PLCG2, PLCgamma, PlcHR2, PlcHR2 toxin, PLCLM, protein kinase C, PtdCho-PLC, Rv3487c, SMase, SMc00171, sphingomyelinase, type C phospholipase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.3 phospholipase C

Activating Compound

Activating Compound on EC 3.1.4.3 - phospholipase C

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
benzothiadiazole
-
rapid activation
cetyltrimethylammonium bromide
-
-
cholesterol
-
phospholipase C is enhanced by cholesterol and by lipids with an intrinsic negative curvature, e.g. phosphatidylethanolamine
diethyl ether
-
substrate: sphingomyelin
dithiothreitol
-
-
ethyl ether
-
C-1
G-protein subunit complex beta-gamma
-
G-protein subunit complex
-
GTPgammaS
-
isoform acting on inositol-phosphatidylinositol-4,5-bisphosphate
guanine nucleotide-binding protein G16alpha
-
guanine nucleotide-binding regulatory protein Gh
-
stimulating only in presence of GTPgammaS, lowers required Ca2+ concentration
-
guanine nucleotide-binding regulatory protein Ghalpha
-
stimulation in presence of aluminium fluoride, lowers required Ca2+ concentration
-
H2O2
-
exogenous H2O2 increases enzyme activity
histone
-
PLC d1 and PLC d3
IL-2
-
stimulates isoform beta1 in vivo within 60 min of treatment
-
liponox DCH
-
at a concentration of 0.1-0.2%
lymphokine
-
activation by lymphokines and/or in lytic granule exocytosis
-
lysozyme
-
PLC d1
-
Melittin
-
PLC d1 and PLC d3
methyl jasmonate
-
rapid activation
methylmercury
-
MeHg, activation of PLC
Mg2+
-
required
moxonidine
-
incubation of CHO cells stably expressing human imidazoline receptor antisera-selected protein IRAS for 5 min can induce an upregulation of isoform PC-PLC activity and an increase in the accumulation of reaction product diacylglycerol
Na+
-
activity is enhanced by 180% with Na+ (500 mM)
Nonidet P-40
-
-
phosphatidylcholine
-
-
phosphatidylethanolamine
-
phospholipase C is enhanced by cholesterol and by lipids with an intrinsic negative curvature, e.g. phosphatidylethanolamine
phosphatidylserine
-
-
putrescine
-
PLC d1
rilmenidine
-
incubation of CHO cells stably expressing human imidazoline receptor antisera-selected protein IRAS for 5 min can induce an upregulation of isoform PC-PLC activity and an increase in the accumulation of reaction product diacylglycerol
salicylic acid
-
rapid activation
silica particle
-
enzyme activity in macrophage increases significantly upon exposure to silica particles. Increase in activity is inhibited by Mn(III)tetrakis(4-benzoic acid)porphyrin chloride
-
sodium cholate
-
-
sodium dehydrocholate
-
-
sodium deoxycholate
spermidine
-
PLC d1
spermine
-
PLC d1 and PLC d3
subunit of cell surface receptor associated G-protein
-
Triton X-100
additional information
-