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3.1.4.3: phospholipase C

This is an abbreviated version!
For detailed information about phospholipase C, go to the full flat file.

Word Map on EC 3.1.4.3

Reaction

a phosphatidylcholine
+
H2O
=
1,2-diacyl-sn-glycerol
 +
phosphocholine

Synonyms

alpha-toxin, Beta toxin, Beta-hemolysin, Beta-toxin, broad-range phospholipase C, Cbp, CegC1, cholinespecific glycerophosphodiester phosphodiesterase, Clostridium oedematiens beta- and gamma-toxins, Clostridium welchii alpha-toxin, cPC-PLC, CpPLC, Dot/Icm-injected effector, Gamma-toxin, haemolytic phospholipase C, Heat labile-hemolysin, heat-labile hemolysin, Hemolysin, hemolytic PLC, hNPP6, Lecithinase, lecithinase C, lipophosphodiesterase C, lipophosphodiesterase I, Lpg0012, mNPP6, More, mPC-PLC, MTP40 antigen, non-specific phospholipase C, nonhemolytic PLC, nonspecific phospholipase C, NPC, NPC1, NPC1a, NPC1b, NPC2, NPC2a, NPC2b, NPC3, NPC3a, NPC3b, NPC4, NPC5, NPC6, NPC6a, NPC6b, NPC6c, NPC6d, NPP6, nucleotide pyrophosphatase/phosphodiesterase, PC-PLC, phosphatidase C, Phosphatidylcholine cholinephosphohydrolase, phosphatidylcholine phospholipase C, phosphatidylcholine specific phospholipase C, phosphatidylcholine-hydrolysing phospholipase C, phosphatidylcholine-hydrolyzing phospholipase C, phosphatidylcholine-preferring PLC, phosphatidylcholine-specific phospholipase C, phospholipase C, phospholipase C beta 1, phospholipase C gamma 1, phospholipase C gamma 2, phospholipase C/sphingomyelinase, phospholipase C/sphingomyelinase HR2, PLC, PLC-Bt, PLC-H, PLC-N, PLC1, PLC2, PlcB, PLCBC, PLCbeta, plcC, PlcC protein, PlcC/CegC1, PLCG1, PLCG2, PLCgamma, PlcHR2, PlcHR2 toxin, PLCLM, protein kinase C, PtdCho-PLC, Rv3487c, SMase, SMc00171, sphingomyelinase, type C phospholipase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.3 phospholipase C

Expression

Expression on EC 3.1.4.3 - phospholipase C

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression of gene NPC4 in root tips is highly induced by NaCl, maximum expression from 3 h to 6 h after the salt treatment dependent on salt concentration
isoforms NPC1a and NPC1b are up-regulated under the treatments of low-phosphate and salt, up-regulated at 1 h and 2 h but then down-regulated under the drought treatment. Under abscisic acid treatment, isoforms NPC1a, NPC2a, NPC2b, NPC3a and NPC3b are up-regulated. Expression of isoforms NPC4, NPC6a and NPC6b is up-regulated under salt treatment. Isoforms NPC6a, NPC6b, NPC6c, and NPC6d are up-regulated at the beginning but then down-regulated under drought treatment
-
isoforms PLCG1 and PLCG2 expression increase at approximately 1-6 h post-lipopolysaccharide injection
-
the enzyme expression is induced by drought, salt, cold, dark, abscisic acid, brassinolide, methyl jasmonate, and gibberellic acid treatments
-
the enzyme is induced by 24-epibrassinolide signalling, auxin, and cytokinin. Expression level of NPC3 is increased 14.6fold after 2 h in seedlings subjected to 37°C heat stress. NPC3 does demonstrate a positive response to Botrytis cinerea, Golovinomyces orontii, Pseudomonas syringae and Phytophthora infestans treatment
the enzyme is induced by phosphate deficiency
the enzyme is upregulated during infection of Acanthamoeba castellanii amoebae and macrophages
the enzyme mRNA expression is down-regulated in patients with schizophrenia
-
under abscisic acid treatment, isoforms NPC1b, NPC6a and NPC6b are down-regulated. Isoforms NPC2a, NPC2b, NPC6a, NPC6b, NPC6c and NPC6d are down-regulated under the treatments of low-phosphate and salt. Isoforms NPC3a and GhNPC3b are both down-regulated under salt treatment. Expression of isoform NPC4 is down-regulated under drought treatment
-