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1,2-diacyl-sn-glycero-3-phosphatide + H2O
1,2-diacylglycerol + phosphate
-
-
-
?
1,2-dibutyryl-sn-glycero-3-phosphocholine + H2O
1,2-dibutyryl-sn-glycerol + phosphocholine
-
-
-
-
?
1,2-dicaproylphosphatidylcholine + H2O
1,2-dicaproylglycerol + phosphorylcholine
-
-
-
?
1,2-diheptanoyl-sn-glycero-3-phosphocholine + H2O
1,2-diheptanoyl-sn-glycerol + phosphocholine
-
-
-
-
?
1,2-dihexanoyl-sn-glycero-3-phospho-L-serine + H2O
1,2-dihexanoyl-sn-glycerol + phosphorylserine
-
-
?
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O
1,2-dihexanoyl-sn-glycerol + phosphocholine
-
-
-
-
?
1,2-dihexanoyl-sn-glycero-3-phosphocholine + H2O
1,2-dihexanoyl-sn-glycerol + phosphorylcholine
-
-
?
1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + H2O
1,2-dihexanoyl-sn-glycerol + phosphoethanolamine
1,2-dilauroylphosphatidylcholine + H2O
1,2-dilaureoylglycerol + phosphorylcholine
-
-
-
?
1,2-dimyristoylphosphatidylcholine + H2O
1,2-dimyristoylglycerol + phosphorylcholine
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) + H2O
1,2-dioleoyl-sn-glycerol + glycerol 1-phosphate
-
about 25% activity compared to 1,2-dioleoyl-sn-glycero-3-phosphocholine
-
-
?
1,2-dioleoyl-sn-glycero-3-phospho-L-serine + H2O
1,2-dioleoyl-sn-glycerol + phospho-L-serine
-
60% activity compared to 1,2-dioleoyl-sn-glycero-3-phosphocholine
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphocholine + H2O
1,2-dioleoyl-sn-glycerol + phosphocholine
-
100% activity
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + H2O
1,2-dioleoyl-sn-glycerol + phosphoethanolamine
-
about 70% activity compared to 1,2-dioleoyl-sn-glycero-3-phosphocholine
-
-
?
1,2-dioleoylphosphatidylcholine + H2O
1,2-dioleoylglycerol + phosphorylcholine
-
-
-
?
1,2-dioleoylphosphatidylethanolamine + H2O
1,2-dioleoylglycerol + phosphorylethanolamine
1,2-dipalmitoylphosphatidylcholine + H2O
1,2-dipalmitoylglycerol + phosphorylcholine
1,2-dipalmitoylphosphatidylethanolamine + H2O
1,2-dipalmitoylglycerol + phosphorylethanolamine
-
-
-
?
1-acyl-2-linoleoyl-glycerophosphocholine
?
1-arachidonoyl-2-lysophosphatidylcholine + H2O
1-arachidonoyl-sn-glycerol + phosphorylcholine
best substrate
-
-
?
1-arachidoyl-2-lysophosphatidylcholine + H2O
1-arachidoyl-sn-glycerol + phosphorylcholine
poor substrate
-
-
?
1-lauroyl-lysophosphatidylcholine + H2O
1-lauroyl-sn-glycerol + phosphorylcholine
potent substrate
-
-
?
1-linoleoyl-lysophosphatidylcholine + H2O
1-linoleoyl-sn-glycerol + phosphorylcholine
second best substrate
-
-
?
1-myristoyl-lysophosphatidylcholine + H2O
1-myristoyl-sn-glycerol + phosphorylcholine
potent substrate
-
-
?
1-O-(6-(p-methyl red)-amino-hexanoyl)-2-O-(12-(p-methyl red)-amino-dodecanoyl)-sn-glyceryl-N-(3-(5-BODIPY-pentanoyl)-amino-propyl)-N,Ndimethyl-phosphatidylethanolamine + H2O
?
-
fluorogenic analogue of phosphatidylcholine, direct substrate for real-time measurement of enzyme activity
-
-
?
1-oleoyl-lysophosphatidylcholine + H2O
1-oleoyl-sn-glycerol + phosphorylcholine
-
-
-
?
1-palmitoyl-2-acyl-glycerophosphocholine
?
1-palmitoyl-2-linoleoyl-glycerophosphocholine
?
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate + choline
the enzyme hydrolyzes 98.4% of mixed micelle 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine in 1 h
-
-
?
1-palmitoyl-lysophosphatidylcholine + H2O
1-palmitoyl-sn-glycerol + phosphorylcholine
1-palmitoyl-lysophosphatidylcholine + H2O
monopalmitoylglycerol + phosphorylcholine
-
-
-
?
1-stearoyl-lysophosphatidylcholine + H2O
1-stearoyl-sn-glycerol + phosphorylcholine
poor substrate
-
-
?
4-nitrophenylphosphorylcholine + H2O
4-nitrophenol + phosphorylcholine
-
-
-
-
?
BODIPY-phosphatidylcholine + H2O
BODIPY-1,2-diacyl-sn-glycerol + phosphorylcholine
-
-
-
-
?
cardiolipin + H2O
phosphatidylglycerophosphate + 1,2-diacylglycerol
ceramide aminoethylphosphonate
N-acylsphingosine + aminoethylphosphonate
-
-
-
?
ceramide phosphorylethanolamine
N-acylsphingosine + phosphorylethanolamine
-
-
-
?
choline plasmalogen
?
-
-
-
-
?
choline plasmalogen + H2O
?
substrate of EC 3.1.4.3
-
-
?
diacylglycerylphosphoryl monomethylethanolamine + H2O
?
diheptanoylphosphatidylcholine + H2O
diheptanoylglycerol + phosphorylcholine
-
-
-
?
dihexanoylphosphatidic acid + H2O
?
-
-
-
-
?
dihexanoylphosphatidylcholine + H2O
dihexanoylglycerol + phosphorylcholine
-
-
-
?
dimyristoylphosphatidylcholine + H2O
dimyristoylglycerol + phosphorylcholine
-
substrate in mixed micelles with sodium deoxycholate
-
-
?
egg lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
NPP6 is a choline-specific glycerophosphodiester phosphodiesterase. In marked difference to NPP2 (lysoPLD/autotaxin), which equally hydrolyzes lysophosphatidylcholine, 1-oleoyl lysophosphatidylethanolamine, 1-oleoyl lysophosphatidylserine, and porcine liver lysophosphatidylinositol to form lysophosphatidic acid, NPP6 hydrolyzes only lysophosphatidylcholine
-
-
?
glucosaminylphosphatidylglycerol + H2O
?
-
-
-
-
?
glycan-phosphatidylinositol + H2O
?
glycerophosphorylcholine + H2O
glycerol + phosphorylcholine
enzyme hydrolyzes GPC efficiently, measurement of GDE activity
-
-
?
L-alpha-lysophosphatidylcholine + H2O
?
substrate of EC 3.1.4.3
-
-
?
lysocholinephospholipid + H2O
?
-
-
-
?
lysoPAF + H2O
?
lyso platelet activating factor, partially hydrolyzed
-
-
?
lysophosphatidylcholine
?
lysophosphatidylcholine + H2O
?
-
-
-
?
lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
membrane form variant surface glycoproteins + H2O
soluble variant surface glycoprotein + sn-1,2-dimyristoylglycerol
p-nitrophenyl phenylphosphate + H2O
?
pNPPP, classical NPP substrate
-
-
?
p-nitrophenyl phenylphosphate + H2O
p-nitrophenol + phenylphosphate
pNPPP, classical NPP substrate
-
-
?
p-nitrophenyl phosphorylcholine + H2O
?
recombinant NPP6 efficiently hydrolyzes the classical substrate for phospholipase C
-
-
?
p-nitrophenyl phosphorylcholine + H2O
? + p-nitrophenol
pNPPC, classical NPP substrate
-
-
?
p-nitrophenyl phosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
pNPPC, classical NPP substrate, recombinant NPP6 efficiently hydrolyzes the classical substrate for phospholipase C
-
-
?
p-nitrophenylphosphoryl-choline + H2O
p-nitrophenol + phosphorylcholine
-
-
-
-
?
p-nitrophenylphosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
phosphatidic acid + H2O
1,2-diacyl-sn-glycerol + phosphate
-
specific for
-
-
?
phosphatidic acid + H2O
1,2-sn-diacylglycerol + phosphate
-
-
-
?
phosphatidic acid + H2O
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + choline phosphate
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + phosphorylcholine
phosphatidylcholine + H2O
1,2-diacylglycerol + choline phosphate
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
phosphatidylethanolamine + H2O
1,2-diacyl-sn-glycerol + ethanolamine phosphate
phosphatidylethanolamine + H2O
1,2-diacyl-sn-glycerol + phosphoethanolamine
-
-
-
-
?
phosphatidylethanolamine + H2O
1,2-sn-diacylglycerol + phosphoethanolamine
phosphatidylethanolamine + H2O
phosphorylethanolamine + 1,2-diacylglycerol
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
phosphatidylglycerol + H2O
1,2-diacylglycerol + sn-glycerol-3-phosphate
phosphatidylglycerol + H2O
1,2-sn-diacylglycerol + sn-glycerol-3-phosphate
phosphatidylinositol + H2O
1,2-sn-diacylglycerol + phosphoinositol
phosphatidylinositol + H2O
inositol monophosphate + diacylglycerol
phosphatidylinositol 4,5-bisphosphate + H2O
inositol 4,5-bisphosphate + phosphatidate
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
phosphatidylserine + H2O
phosphorylserine + diacylglycerol
plasmalogen + H2O
?
-
-
-
-
?
platelet activating factor + H2O
?
PAF, partially hydrolyzed
-
-
?
sphingomyelin + H2O
ceramide + phosphocholine
sphingomyelin + H2O
ceramide + phosphorylcholine
sphingomyelin + H2O
N-acylsphingosine + choline phosphate
sphingosylphosphorylcholine + H2O
?
SPC, measurement of lysoPLC activity of NPP6 toward choline-containing phospholipids
-
-
?
additional information
?
-
1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + H2O
1,2-dihexanoyl-sn-glycerol + phosphoethanolamine
-
-
?
1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + H2O
1,2-dihexanoyl-sn-glycerol + phosphoethanolamine
-
less efficient substrate
-
-
?
1,2-dioleoylphosphatidylethanolamine + H2O
1,2-dioleoylglycerol + phosphorylethanolamine
-
-
-
?
1,2-dioleoylphosphatidylethanolamine + H2O
1,2-dioleoylglycerol + phosphorylethanolamine
-
-
-
?
1,2-dipalmitoylphosphatidylcholine + H2O
1,2-dipalmitoylglycerol + phosphorylcholine
-
-
-
?
1,2-dipalmitoylphosphatidylcholine + H2O
1,2-dipalmitoylglycerol + phosphorylcholine
-
-
-
?
1,2-dipalmitoylphosphatidylcholine + H2O
1,2-dipalmitoylglycerol + phosphorylcholine
-
-
-
-
?
1,2-dipalmitoylphosphatidylcholine + H2O
1,2-dipalmitoylglycerol + phosphorylcholine
-
-
-
?
1,2-dipalmitoylphosphatidylcholine + H2O
1,2-dipalmitoylglycerol + phosphorylcholine
-
-
-
?
1,2-dipalmitoylphosphatidylcholine + H2O
1,2-dipalmitoylglycerol + phosphorylcholine
-
-
-
-
?
1-acyl-2-linoleoyl-glycerophosphocholine
?
-
-
-
-
?
1-acyl-2-linoleoyl-glycerophosphocholine
?
-
-
-
-
?
1-palmitoyl-2-acyl-glycerophosphocholine
?
-
-
-
-
?
1-palmitoyl-2-acyl-glycerophosphocholine
?
-
-
-
-
?
1-palmitoyl-2-linoleoyl-glycerophosphocholine
?
-
-
-
-
?
1-palmitoyl-2-linoleoyl-glycerophosphocholine
?
-
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + H2O
1-palmitoyl-sn-glycerol + phosphorylcholine
-
-
-
?
1-palmitoyl-lysophosphatidylcholine + H2O
1-palmitoyl-sn-glycerol + phosphorylcholine
-
-
-
-
?
cardiolipin + H2O
phosphatidylglycerophosphate + 1,2-diacylglycerol
-
-
-
?
cardiolipin + H2O
phosphatidylglycerophosphate + 1,2-diacylglycerol
-
-
-
?
diacylglycerylphosphoryl monomethylethanolamine + H2O
?
-
-
-
-
?
diacylglycerylphosphoryl monomethylethanolamine + H2O
?
-
-
-
-
?
glycan-phosphatidylinositol + H2O
?
-
-
-
-
?, r
glycan-phosphatidylinositol + H2O
?
-
-
-
-
?, r
lysophosphatidylcholine
?
-
-
-
-
?
lysophosphatidylcholine
?
-
-
-
-
?
lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
-
-
-
?
lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
-
-
-
?
lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
-
-
-
?
lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
-
-
-
?
lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
-
-
-
?
lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
-
-
-
?
lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
-
-
-
?
lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
-
-
-
?
lysophosphatidylcholine + H2O
monoacylglycerol + phosphorylcholine
-
-
-
?
membrane form variant surface glycoproteins + H2O
soluble variant surface glycoprotein + sn-1,2-dimyristoylglycerol
-
-
-
?
membrane form variant surface glycoproteins + H2O
soluble variant surface glycoprotein + sn-1,2-dimyristoylglycerol
-
-
-
?
p-nitrophenylphosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
-
-
-
-
?
p-nitrophenylphosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
-
-
-
-
?
p-nitrophenylphosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
-
-
-
-
?
p-nitrophenylphosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
-
-
-
?
p-nitrophenylphosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
-
-
-
?
p-nitrophenylphosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
-
-
-
?
p-nitrophenylphosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
-
-
-
-
?
p-nitrophenylphosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
-
-
-
-
?
phosphatidic acid + H2O
?
-
-
-
-
?
phosphatidic acid + H2O
?
-
9.04% of the activity with phosphatidylcholine
-
-
?
phosphatidic acid + H2O
?
-
9.04% of the activity with phosphatidylcholine
-
-
?
phosphatidic acid + H2O
?
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + choline phosphate
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + choline phosphate
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + choline phosphate
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + choline phosphate
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + choline phosphate
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + choline phosphate
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + choline phosphate
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + choline phosphate
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + phosphorylcholine
-
preferred substrate
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacyl-sn-glycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
Clostridium welchii
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
substrate from egg yolk
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
hemolytic PLC
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
nonhemolytic PLC
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
phosphatidylcholine and sphingomyelin are cleaved at equal rate
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
substrate from egg yolk
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-diacylglycerol + phosphorylcholine
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
the enzyme shows cell-associated phosphatidylcholine-specific phospholipase C activity in vivo
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
the enzyme shows cell-associated phosphatidylcholine-specific phospholipase C activity in vivo
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylcholine + H2O
1,2-sn-diacylglycerol + phosphocholine
-
-
-
-
?
phosphatidylethanolamine + H2O
1,2-diacyl-sn-glycerol + ethanolamine phosphate
-
-
-
-
?
phosphatidylethanolamine + H2O
1,2-diacyl-sn-glycerol + ethanolamine phosphate
-
-
-
-
?
phosphatidylethanolamine + H2O
1,2-sn-diacylglycerol + phosphoethanolamine
-
-
-
?
phosphatidylethanolamine + H2O
1,2-sn-diacylglycerol + phosphoethanolamine
-
-
-
-
?
phosphatidylethanolamine + H2O
1,2-sn-diacylglycerol + phosphoethanolamine
-
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + 1,2-diacylglycerol
-
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + 1,2-diacylglycerol
-
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + 1,2-diacylglycerol
-
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylethanolamine + H2O
phosphorylethanolamine + diacylglycerol
-
-
-
?
phosphatidylglycerol + H2O
1,2-diacylglycerol + sn-glycerol-3-phosphate
-
-
-
?
phosphatidylglycerol + H2O
1,2-diacylglycerol + sn-glycerol-3-phosphate
-
-
-
?
phosphatidylglycerol + H2O
1,2-sn-diacylglycerol + sn-glycerol-3-phosphate
-
-
-
?
phosphatidylglycerol + H2O
1,2-sn-diacylglycerol + sn-glycerol-3-phosphate
-
-
-
?
phosphatidylinositol + H2O
1,2-sn-diacylglycerol + phosphoinositol
-
-
-
?
phosphatidylinositol + H2O
1,2-sn-diacylglycerol + phosphoinositol
-
-
-
?
phosphatidylinositol + H2O
inositol monophosphate + diacylglycerol
-
-
-
?
phosphatidylinositol + H2O
inositol monophosphate + diacylglycerol
-
-
-
?
phosphatidylinositol + H2O
inositol monophosphate + diacylglycerol
-
-
-
?
phosphatidylinositol + H2O
inositol monophosphate + diacylglycerol
-
Ca2+-dependent activity
-
?
phosphatidylinositol + H2O
inositol monophosphate + diacylglycerol
-
-
-
?
phosphatidylinositol + H2O
inositol monophosphate + diacylglycerol
-
-
-
?
phosphatidylinositol + H2O
inositol monophosphate + diacylglycerol
-
-
-
?
phosphatidylinositol + H2O
inositol monophosphate + diacylglycerol
-
-
-
?
phosphatidylinositol + H2O
inositol monophosphate + diacylglycerol
-
-
-
?
phosphatidylinositol + H2O
inositol monophosphate + diacylglycerol
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
inositol 4,5-bisphosphate + phosphatidate
-
Ca2+-independent activity
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
inositol 4,5-bisphosphate + phosphatidate
-
-
-
?
phosphatidylinositol 4,5-bisphosphate + H2O
inositol 4,5-bisphosphate + phosphatidate
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylinositol-bisphosphate + H2O
inositol 1,4,5-trisphosphate + 1,2-diacylglycerol
-
-
-
?
phosphatidylserine + H2O
phosphorylserine + diacylglycerol
-
-
-
?
phosphatidylserine + H2O
phosphorylserine + diacylglycerol
-
-
-
?
phosphatidylserine + H2O
phosphorylserine + diacylglycerol
-
-
-
?
phosphatidylserine + H2O
phosphorylserine + diacylglycerol
-
-
-
-
?
phosphatidylserine + H2O
phosphorylserine + diacylglycerol
-
-
-
?
phosphatidylserine + H2O
phosphorylserine + diacylglycerol
-
-
-
?
phosphatidylserine + H2O
phosphorylserine + diacylglycerol
-
-
-
?
phosphatidylserine + H2O
phosphorylserine + diacylglycerol
-
nonhemolytic PLC
-
-
?
phosphatidylserine + H2O
phosphorylserine + diacylglycerol
-
-
-
?
phosphatidylserine + H2O
phosphorylserine + diacylglycerol
-
-
-
?
sphingomyelin + H2O
ceramide + phosphocholine
-
about 70% activity compared to 1,2-dioleoyl-sn-glycero-3-phosphocholine
-
-
?
sphingomyelin + H2O
ceramide + phosphocholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
when substrate is presented in a biological membrane, for example in the human red cell membrane or myelin sheath
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
hemolytic PLC
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
phosphatidylcholine and sphingomyelin are cleaved at equal rate
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
ceramide + phosphorylcholine
-
-
-
?
sphingomyelin + H2O
N-acylsphingosine + choline phosphate
-
-
-
-
?
sphingomyelin + H2O
N-acylsphingosine + choline phosphate
-
-
-
-
?
sphingomyelin + H2O
N-acylsphingosine + choline phosphate
-
-
-
-
?
triolein + H2O
?
-
-
-
?
additional information
?
-
-
PLCBC also catalyzes the hydrolysis of phosphatidylethanolamine and phosphatidylserine but with lower efficiency
-
-
?
additional information
?
-
-
modeling of active site and reaction mechanism, development of two different reaction mechanism models, overview
-
-
?
additional information
?
-
-
phospholipase C can catalyze the membrane fusion between cell membranes and phospholipid vehicles (liposomes) at pH 4.0-7.5, highest activity at pH 5.0, 37°C. The liposomes are composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, and cholesterol in a 1:1:1 molar ratio, membrane fusion is dependent of the lipid composition, overview. The enzyme takes a molten-globule state, with a large fluctuation at acidic pH, mechanism of enzyme-induced membrane fusion
-
-
?
additional information
?
-
enzyme is not haemolytic for human erythrocytes and not involved in multinucleated giant cell formation or induction of apoptotic cell death
-
-
?
additional information
?
-
-
enzyme is not haemolytic for human erythrocytes and not involved in multinucleated giant cell formation or induction of apoptotic cell death
-
-
?
additional information
?
-
-
the release of Ca2+ from the intracellular calcium stores after application of ATP or carbachol is mediated by phospholipase C
-
-
?
additional information
?
-
-
the enzyme is the major virulence factor in the pathogenesis of gas gangrene. Reduction in gangliosides renders cells more susceptible to the membrane f´damage caused by Cp-PLC
-
-
?
additional information
?
-
-
substrate specificity analysis by molecular docking reveals that the enzyme is also active with phosphatidylethanolamine and phosphatidylinositol, and to a lower level with phosphatidylglycerol, overview
-
-
?
additional information
?
-
-
substrate specificity analysis by molecular docking reveals that the enzyme is also active with phosphatidylethanolamine and phosphatidylinositol, and to a lower level with phosphatidylglycerol, overview
-
-
?
additional information
?
-
-
the signaling pathway of human imidazoline receptor antisera-selected protein IRAS in response to I1-imidazoline receptor agonists is coupled with the activation of isoform PC-PLC and its downstream signal transduction molecule ERK
-
-
?
additional information
?
-
-
isoform PC-PLC and reactive oxygen species are involved in chicken blastodisc differentiation to vascular endothelial cells
-
-
?
additional information
?
-
-
isoform PC-PLC plays an important role in regulating CD16 receptor membrane expression, the CD16-mediated cytolytic mechanism and CD16-triggered signal transduction
-
-
?
additional information
?
-
-
isoforms phosphatidylcholine-specific phospholipase C, i.e. PC-PLC, and phosphatidylinositol-specific phospholipase C, i.e. PI-PLC, control apoptosis by jointly regulating Akt phosphorylation, p53 expression, and affecting cell cycle in vascular endothelial cells
-
-
?
additional information
?
-
release of nucleoside 5'-monophosphate from a variety of nucleotides and nucleotide derivatives
-
-
?
additional information
?
-
-
release of nucleoside 5'-monophosphate from a variety of nucleotides and nucleotide derivatives
-
-
?
additional information
?
-
recombinant NPP6 does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate (pNP-TMP) and bis(p-nitrophenyl) phosphate. NPP6 does not act on sphingomyelin (SM)
-
-
?
additional information
?
-
-
recombinant NPP6 does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate (pNP-TMP) and bis(p-nitrophenyl) phosphate. NPP6 does not act on sphingomyelin (SM)
-
-
?
additional information
?
-
the recombinant enzyme hydrolyzes a broad phospholipid spectrum, including phosphatidylcholine, phosphatidylglycerol, and phosphatidylinositol, broad substrate preference
-
-
?
additional information
?
-
-
the recombinant enzyme hydrolyzes a broad phospholipid spectrum, including phosphatidylcholine, phosphatidylglycerol, and phosphatidylinositol, broad substrate preference
-
-
?
additional information
?
-
the recombinant enzyme hydrolyzes a broad phospholipid spectrum, including phosphatidylcholine, phosphatidylglycerol, and phosphatidylinositol, broad substrate preference
-
-
?
additional information
?
-
-
the enzyme induces membrane fusion
-
-
?
additional information
?
-
-
no activity with phosphatidylinositol
-
-
?
additional information
?
-
-
the enzyme induces membrane fusion
-
-
?
additional information
?
-
release nucleoside 5'-monophosphate from a variety of nucleotides and nucleotide derivatives
-
-
?
additional information
?
-
-
the enzyme plays a key role in the pathogenesis of bacterial infection
-
-
?
additional information
?
-
-
the enzyme plays a key role in the pathogenesis of bacterial infection
-
-
?
additional information
?
-
-
the enzyme plays a key role in the pathogenesis of bacterial infection
-
-
?
additional information
?
-
-
the enzyme plays a key role in the pathogenesis of bacterial infection
-
-
?
additional information
?
-
-
phospholipase C hydrolyzes phosphatidylethanolamine and phosphatidylcholine but not other glycerophospholipids
-
-
?
additional information
?
-
-
phospholipase C hydrolyzes phosphatidylethanolamine and phosphatidylcholine but not other glycerophospholipids
-
-
?
additional information
?
-
-
enzyme activity is necessary for PLC-induced inflammation
-
-
?
additional information
?
-
-
hemolytic fractions from strain ATCC 19660 cause paralysis, death, dermonecrosis, footpad swelling, and vascular permeability in mice. The toxicity is directly associated with enzymatic activity
-
-
?
additional information
?
-
-
homoserine lactone-mediated quorum sensing regulates the expression of PA0026, which encodes PlcB. PlcB is required for directed twitching motility up a gradient of certain kinds of phospholipids
-
-
?
additional information
?
-
-
phospholipase C causes platelet aggregation in a concentration-dependent manner
-
-
?
additional information
?
-
-
phospholipase C plays a role in pathogenesis of infections by Pseudomonas aeruginosa
-
-
?
additional information
?
-
-
the enzyme, when injected intradermally into the skin of sheep, elicits histopathological lesions virtually identical to that seen in naturally occuring fleecerot
-
-
?
additional information
?
-
-
the catalytic activity of enyme induces substrate vesicle fusion without relase of vesicular content. The presence of phosphatidylserine in the vesicle composition does not modify significantly enzyme. Induced liposome aggregation, but completely abolishes fusion. Enzyme is inactive on phospholipids that lack choline head groups
-
-
?
additional information
?
-
-
The sphingomyelinase, but not the phospholipase C activity, is essential for induction of hot-cold hemolysis in human erythrocytes, that contain both phosphatidylcholine and sphingomyelin but also in goat erythrocytes, which lack phosphatidylcholine, however, in horse erythrocytes, with a large proportion of phosphatidylcholine and almost no sphingomyelin, hot-cold hemolysis induced by PlcHR2 is not observed, overview
-
-
?
additional information
?
-
-
PlcHR2 toxin from Pseudomonas aeruginosa is an enzyme with both phospholipase C and sphingomyelinase activities, PlcHR2 hydrolyzes phosphatidylcholine and sphingomyelin at similar rates, but other phospholipids are cleaved at much lower rates, if at all
-
-
?
additional information
?
-
-
activity measurement with substrate on giant unilamellar lipid vesicles. Enzyme binding to the vesicles appears to be a cooperative process and is irreversible, binding analysis using wild-type enzyme and catalytically inactive enzyme mutant T178A. After the initial cluster of bound enzyme is detected, further binding and catalytic activity follow rapidly. The enzyme preferentially binds the more disordered domains, and, in most cases, the catalytic activity causes the disordering of the other domains, at a further stage of lipid hydrolysis, lipid aggregates are formed and vesicles disintegrate, overview
-
-
?
additional information
?
-
-
PlcHR2 is a secreted toxin that exhibits phospholipase C and sphingomyelinase activities. It shows hydrolytic activity of PlcHR2 on bilayers of varying lipid compositions, e.g. on giant unilamellar vesicles composed of sphingomyelin, phosphatidylcholine, phosphatidylethanolamine, and cholesterol
-
-
?
additional information
?
-
-
phosphatidylethanolamine, sphingomyelin, phosphatidylinositol and phosphatidylserine are hydrolyzed at less than 1% of the activity with phosphatidylcholine
-
-
?
additional information
?
-
-
phosphatidylethanolamine, sphingomyelin, phosphatidylinositol and phosphatidylserine are hydrolyzed at less than 1% of the activity with phosphatidylcholine
-
-
?
additional information
?
-
-
enzyme induces cell cycle progression, overexpression of enzyme induces overexpression of cyclin D3
-
?
additional information
?
-
-
enzyme is regulated through redox- and calcium-dependent manners in alveolar macrophage
-
-
?
additional information
?
-
-
low isoform PC-PLC activity is required for mesenchymal stem cell neuronal differentiation, and basic fibroblast growth factor is necessary for maintaining the neuronal differentiation state
-
-
?
additional information
?
-
-
interaction between PC-PLC and cell division cycle 20 homologue, Cdc20, initiating the degradation of PC-PLC by Cdc20-mediated ubiquitin proteasome pathway
-
-
?
additional information
?
-
the enzyme prefers mixed micelle substrates to liposomal substrates. The rate-limiting steps of hydrolysis of mixed micelle 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and emulsified lysophosphatidylcholine are the bulk step and the surface step, respectively
-
-
?
additional information
?
-
-
cPC-PLC may contribute to the parasite evasion against the host immune response
-
-
?
additional information
?
-
-
mPC-PLC may play a role in the intercellular multiplication of Uronema marinum
-
-
?
additional information
?
-
-
no activity with phosphatidylinositol and phosphatidylethanolamine
-
-
?