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3.1.4.3: phospholipase C

This is an abbreviated version!
For detailed information about phospholipase C, go to the full flat file.

Word Map on EC 3.1.4.3

Reaction

a phosphatidylcholine
+
H2O
=
1,2-diacyl-sn-glycerol
 +
phosphocholine

Synonyms

alpha-toxin, Beta toxin, Beta-hemolysin, Beta-toxin, broad-range phospholipase C, Cbp, CegC1, cholinespecific glycerophosphodiester phosphodiesterase, Clostridium oedematiens beta- and gamma-toxins, Clostridium welchii alpha-toxin, cPC-PLC, CpPLC, Dot/Icm-injected effector, Gamma-toxin, haemolytic phospholipase C, Heat labile-hemolysin, heat-labile hemolysin, Hemolysin, hemolytic PLC, hNPP6, Lecithinase, lecithinase C, lipophosphodiesterase C, lipophosphodiesterase I, Lpg0012, mNPP6, More, mPC-PLC, MTP40 antigen, non-specific phospholipase C, nonhemolytic PLC, nonspecific phospholipase C, NPC, NPC1, NPC1a, NPC1b, NPC2, NPC2a, NPC2b, NPC3, NPC3a, NPC3b, NPC4, NPC5, NPC6, NPC6a, NPC6b, NPC6c, NPC6d, NPP6, nucleotide pyrophosphatase/phosphodiesterase, PC-PLC, phosphatidase C, Phosphatidylcholine cholinephosphohydrolase, phosphatidylcholine phospholipase C, phosphatidylcholine specific phospholipase C, phosphatidylcholine-hydrolysing phospholipase C, phosphatidylcholine-hydrolyzing phospholipase C, phosphatidylcholine-preferring PLC, phosphatidylcholine-specific phospholipase C, phospholipase C, phospholipase C beta 1, phospholipase C gamma 1, phospholipase C gamma 2, phospholipase C/sphingomyelinase, phospholipase C/sphingomyelinase HR2, PLC, PLC-Bt, PLC-H, PLC-N, PLC1, PLC2, PlcB, PLCBC, PLCbeta, plcC, PlcC protein, PlcC/CegC1, PLCG1, PLCG2, PLCgamma, PlcHR2, PlcHR2 toxin, PLCLM, protein kinase C, PtdCho-PLC, Rv3487c, SMase, SMc00171, sphingomyelinase, type C phospholipase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.3 phospholipase C

Molecular Weight

Molecular Weight on EC 3.1.4.3 - phospholipase C

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
-
PLC beta 1 isoform
127000
-
gel filtration
128000
-
SDS-PAGE
130000
-
PLC beta 4, isoforms with slightly different MW exist
135000
Western blot analysis
140000
145000
-
PLC gamma 1
150000
152000
-
PLC beta 3
17000
-
1 * 79000 + 1 * 17000, SDS-PAGE
18000
-
gel filtration, C-1 and C-2
23000
28500
29000
-
SDS-PAGE
31000
-
gel filtration
32000
-
SDS-PAGE
35000
36000
-
gel filtration
38000
39000
-
SDS-PAGE
40000
-
two PC-PLC isoforms, 40 and 66 kDa. The same PC-PLC isoforms are also detected in some leukemia cells, such as K562 and DAUDI. In U937 cells only the 40 kDa isoform is detected
46000
-
x * 46000, deduced from gene sequence
47000
-
gel filtration
50000
Western blotting analysis using anti-hNPP6 monoclonal antibody
50000 - 54000
-
SDS-PAGE
60090
x * 60090, sequence calculation
66000
70000
-
x * 70000, SDS-PAGE
72800
-
x * 72800, truncated recombinant protein with His6-tag, SDS-PAGE
76000
-
gel filtration
77000
x * 77000, calculated
78000
79000
-
1 * 79000 + 1 * 17000, SDS-PAGE
80000
-
x * 80000, SDS-PAGE
83000
-
SDS-PAGE
85000
-
PLC delta 1 and PLC delta 2
85100
-
PLC delta 3, gel electrophoresis
85500
-
PLC delta 1, gel electrophoresis