Literature summary for 3.1.4.3 extracted from

Kozasa, T.; Hepler, J.R.; Smrcka, A.V.; Simon, M.I.; Rhee, S.G.; Sternweis, P.C.; Gilman, A.G.
Purification and characterization of recombinant G16alpha from Sf9 cells: Activation of purified phospholipase C isoenzymes by G-protein alpha subunits (1993), Proc. Natl. Acad. Sci. USA, 90, 9176-9180.

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Activating Compound

Activating Compound	Comment	Organism	Structure
G-protein subunit complex beta-gamma	G-protein subunit complex	Rattus norvegicus
guanine nucleotide-binding protein G16alpha	subunit of cell surface receptor associated G-protein, PLC-beta 1, -beta 2 and -beta 3, half-maximal concentration needed for activation is 1nM, stimulating only in presence of GTP gamma S	Rattus norvegicus
guanine nucleotide-binding protein G16alpha	subunit of cell surface receptor associated G-protein, PLC-beta 1, -beta 2 and -beta 3, half-maximal concentration needed for activation is 1nM, stimulating only in presence of GTP gamma S	Bos taurus
subunit of cell surface receptor associated G-protein	Gqa, subunit of cell surface receptor associated G-protein, PLC d1	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
phosphatidylinositol-bisphosphate + H2O	Rattus norvegicus	-	inositol 1,4,5-trisphosphate + 1,2-diacylglycerol	-	?
phosphatidylinositol-bisphosphate + H2O	Bos taurus	-	inositol 1,4,5-trisphosphate + 1,2-diacylglycerol	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	cow	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus
-	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
brain	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphatidylinositol-bisphosphate + H2O	-	Rattus norvegicus	inositol 1,4,5-trisphosphate + 1,2-diacylglycerol	-	?
phosphatidylinositol-bisphosphate + H2O	-	Bos taurus	inositol 1,4,5-trisphosphate + 1,2-diacylglycerol	-	?

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Release 2023.1 (January 2023)